Chagas disease caused by the parasite Trypanosoma cruzi affects millions of people.
Although its first genome dates from 2005, its complexity hindered a complete assembly and …

The Trypanosoma cruzi genome contains the most widely expanded content (∼ 12,000
genes) of the trypanosomatids sequenced to date. This expansion is reflected in the high …

Although the genome of Trypanosoma cruzi, the causative agent of Chagas disease, was
first made available in 2005, with additional strains reported later, the intrinsic genome …

Background The Trypanosoma cruzi genome was sequenced from a hybrid strain (CL
Brener). However, high allelic variation and the repetitive nature of the genome have …

The pathway for RNA interference is widespread in metazoans and participates in numerous
cellular tasks, from gene silencing to chromatin remodeling and protection against …

Transposable elements (TEs) are dynamic elements that can reshape host genomes by
generating rearrangements with the potential to create or disrupt genes, to shuffle existing …

Like in most eukaryotes, the linear chromosomes of Trypanosoma cruzi end in a
nucleoprotein structure called the telomere, which is preceded by regions of variable length …

Trypanosomatids are flagellate protozoans that can infect several invertebrate and
vertebrate hosts, including insects and humans. The three most studied species are the …

Trypanosoma cruzi is the causative agent of Chagas disease, which causes 10,000 deaths
per year. Despite the high mortality associated with Chagas, relatively few parasite genomes …

Trypanosoma cruzi comprises a pool of populations which are genetically diverse in terms of
DNA content, growth and infectivity. Inter-and intra-strain karyotype heterogeneities have …