Targeting cariogenic pathogens and promoting competitiveness of commensal bacteria with a novel pH-responsive antimicrobial peptide

W Jiang, Z Xie, S Huang, Q Huang, L Chen… - Journal of Oral …, 2023 - Taylor & Francis
Novel ecological antimicrobial approaches to dental caries focus on inhibiting cariogenic
pathogens while enhancing the growth of health-associated commensal communities or …

A drug repurposing screen for whipworms informed by comparative genomics

A Coghlan, FA Partridge… - PLOS Neglected …, 2023 - journals.plos.org
Hundreds of millions of people worldwide are infected with the whipworm Trichuris trichiura.
Novel treatments are urgently needed as current drugs, such as albendazole, have relatively …

Structural Requirements for dihydrobenzoxazepinone anthelmintics: Actions against medically important and model parasites: Trichuris muris, Brugia malayi …

FA Partridge, CJR Bataille, R Forman… - ACS Infectious …, 2021 - ACS Publications
Nine hundred million people are infected with the soil-transmitted helminths Ascaris
lumbricoides (roundworm), hookworm, and Trichuris trichiura (whipworm). However, low …

Un-'Egg'-Plored: Characterisation of Embryonation in the Whipworm Model Organism Trichuris muris

R Forman, FA Partridge, DB Sattelle… - Frontiers in Tropical …, 2021 - frontiersin.org
Trichuris muris, is the murine parasite and widely deployed model for the human whipworm
Trichuris trichiura, a parasite that infects around 500 million people globally. Trichuriasis is a …

Actions of Camptothecin Derivatives on Larvae and Adults of the Arboviral Vector Aedes aegypti

FA Partridge, BC Poulton, MAI Lake, RA Lees… - Molecules, 2021 - mdpi.com
Mosquito-borne viruses including dengue, Zika, and Chikungunya viruses, and parasites
such as malaria and Onchocerca volvulus endanger health and economic security around …

A drug repurposing screen for whipworms informed by comparative genomics.

FA Partridge, G Rinaldi, S Clare… - PLoS …, 2023 - westminsterresearch.westminster.ac …
Hundreds of millions of people worldwide are infected with the whipworm Trichuris trichiura.
Novel treatments are urgently needed as current drugs, such as albendazole, have relatively …

[HTML][HTML] Invertebrate neurones, genomes, phenotypic and target-based screening; their contributions to the search for new chemical leads and new molecular targets …

DB Sattelle - Pesticide Biochemistry and Physiology, 2022 - Elsevier
Insect-borne diseases of humans, animals and plants can be devastating. The direct
damage to crops by insect and nematode pests can also severely reduce crop yields and …

[HTML][HTML] High-content phenotypic screening identifies novel chemistries that disrupt mosquito activity and development

MV Murgia, S Sharan, J Kaur, W Austin, L Hagen… - Pesticide Biochemistry …, 2022 - Elsevier
New classes of chemistries are needed to control insecticide resistant populations of
mosquitoes and prevent transmission of vector-borne diseases (VBDs). Organismal screens …

Screening the Medicines for Malaria Venture (MMV) Pandemic Response Box chemical library on Caenorhabditis elegans identifies re-profiled candidate …

M Nick, FA Partridge, R Forman… - Frontiers in Tropical …, 2022 - frontiersin.org
The 3 major classes of soil transmitted helminths (whipworm, hookworm and Ascaris) affect
1.5 billion people worldwide mostly in poor countries, where they have adverse effects on …

Automation Techniques in Tropical Diseases

A Rani - Automated Diagnostic Techniques in Medical …, 2024 - Springer
Tropical diseases are considered to be a threat responsible for causing a large number of
cases and deaths. For controlling these diseases proper surveillance of the vectors like flies …