A growing number of studies point to rapamycin as a pharmacological compound that is
able to provide neuroprotection in several experimental models of neurodegenerative …

Mitochondria are highly dynamic organelles with complex structural features which play
several important cellular functions, such as the production of energy by oxidative …

Alpha-synuclein (αSyn) misfolding is associated with several devastating
neurodegenerative disorders, including Parkinson's disease (PD). In yeast cells and in …

Neurodegenerative disorders such as Parkinson and Alzheimer disease cause motor and
cognitive dysfunction and belong to a heterogeneous group of common and disabling …

Accumulation of misfolded α-synuclein (αS) is mechanistically linked to neurodegeneration
in Parkinson's disease (PD) and other α-synucleinopathies. However, how αS causes …

Human UBIAD1 localizes to mitochondria and converts vitamin K1 to vitamin K2. Vitamin K2
is best known as a cofactor in blood coagulation, but in bacteria it is a membrane-bound …

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene have been shown to cause
autosomal dominant Parkinson's disease. Few mutations in this gene have been identified …

In Parkinson's disease (PD) and other α-synucleinopathies, prefibrillar α-synuclein (αS)
oligomer is implicated in the pathogenesis. However, toxic αS oligomers observed using in …

Oxidative stress has been implicated as playing a role in neurodegenerative disorders, such
as ischemic stroke, Alzheimer's, Huntington's, and Parkinson's disease. Persuasive …

Regulated protein turnover via the ubiquitin–proteasome system (UPS) underlies a wide
variety of signalling pathways, from cell-cycle control and transcription to development …