Local delivery strategies to restore immune homeostasis in the context of inflammation
ER Bentley, SR Little - Advanced drug delivery reviews, 2021 - Elsevier
Immune homeostasis is maintained by a precise balance between effector immune cells and
regulatory immune cells. Chronic deviations from immune homeostasis, driven by a greater …
regulatory immune cells. Chronic deviations from immune homeostasis, driven by a greater …
Combining nanotechnology with monoclonal antibody drugs for rheumatoid arthritis treatments
XK Chi, XL Xu, BY Chen, J Su, YZ Du - Journal of Nanobiotechnology, 2023 - Springer
Rheumatoid arthritis (RA) is a systemic immune disease characterized by synovial
inflammation. Patients with RA commonly experience significant damage to their hand and …
inflammation. Patients with RA commonly experience significant damage to their hand and …
Spatiotemporal regulation of angiogenesis/osteogenesis emulating natural bone healing cascade for vascularized bone formation
X Zhou, J Chen, H Sun, F Wang, Y Wang… - Journal of …, 2021 - Springer
Engineering approaches for growth factor delivery have been considerably advanced for
tissue regeneration, yet most of them fail to provide a complex combination of signals …
tissue regeneration, yet most of them fail to provide a complex combination of signals …
Recombinant protein drugs-based intra articular drug delivery systems for osteoarthritis therapy
H Huang, Y Lin, Y Jiang, Q Yao, R Chen… - European Journal of …, 2023 - Elsevier
Osteoarthritis (OA) is the most prevalent chronic degenerative joint disease. It weakens the
motor function of patients and imposes a significant economic burden on society. The …
motor function of patients and imposes a significant economic burden on society. The …
Single-dose mRNA therapy via biomaterial-mediated sequestration of overexpressed proteins
AS Khalil, X Yu, JM Umhoefer, CS Chamberlain… - Science …, 2020 - science.org
Nonviral mRNA delivery is an attractive therapeutic gene delivery strategy, as it achieves
efficient protein overexpression in vivo and has a desirable safety profile. However, mRNA's …
efficient protein overexpression in vivo and has a desirable safety profile. However, mRNA's …
Local application of mineral-coated microparticles loaded with VEGF and BMP-2 induces the healing of murine atrophic non-unions
Deficient angiogenesis and disturbed osteogenesis are key factors for the development of
nonunions. Mineral-coated microparticles (MCM) represent a sophisticated carrier system …
nonunions. Mineral-coated microparticles (MCM) represent a sophisticated carrier system …
Sustained release and protein stabilization reduce the growth factor dosage required for human pluripotent stem cell expansion
Translation of human pluripotent stem cell (hPSC)-derived therapies to the clinic demands
scalable, cost-effective methods for cell expansion. Culture media currently used for hPSC …
scalable, cost-effective methods for cell expansion. Culture media currently used for hPSC …
Injectable biomaterials for delivery of interleukin-1 receptor antagonist: toward improving its therapeutic effect
AEB Clements, WL Murphy - Acta Biomaterialia, 2019 - Elsevier
Abstract Interleukin-1 receptor antagonist (IL-1Ra) is a naturally occurring anti-inflammatory
cytokine that inhibits IL-1 activity and has been proposed to treat a wide variety of systemic …
cytokine that inhibits IL-1 activity and has been proposed to treat a wide variety of systemic …
Sequential sequestrations increase the incorporation and retention of multiple growth factors in mineralized collagen scaffolds
AS Tiffany, MJ Dewey, BAC Harley - RSC advances, 2020 - pubs.rsc.org
Trauma induced injuries of the mouth, jaw, face, and related structures present unique
clinical challenges due to their large size and complex geometry. Growth factor signaling …
clinical challenges due to their large size and complex geometry. Growth factor signaling …
IL-1 receptor antagonist: etiological and drug delivery systems overview
A Ubhe - Inflammation Research, 2024 - Springer
Objective This article is aims to provide an overview of studies reported in the literature to
investigate the etiological role of IL-1/IL-1ra in various disease conditions and the different …
investigate the etiological role of IL-1/IL-1ra in various disease conditions and the different …