The discovery of the P2X7 receptor (P2X7R, originally named P2Z) in immune cells, its
cloning, and the identification of its role in a multiplicity of immune-mediated diseases raised …

CD39 is a marker of immune cells such as lymphocytes and monocytes. The CD39/CD73
pathway hydrolyzes ATP into adenosine, which has a potent immunosuppressive effect …

Introduction A group of SARS-CoV-2 infected individuals present lingering symptoms,
defined as long COVID (LC), that may last months or years post the onset of acute disease …

Ectonucleotidases modulate inflammatory responses by balancing extracellular ATP and
adenosine (ADO) and might be involved in COVID-19 immunopathogenesis. Here, we …

This study aimed to characterize the changes in serum inflammatory mediators in
hospitalized patients with COVID-19 correlating with death. The study includes 58 …

Three years after the pandemic, we still have an imprecise comprehension of the pathogen
landscape and we are left with an urgent need for early detection methods and effective …

Purinergic signaling modulates immune function and is involved in the
immunopathogenesis of several viral infections. This study aimed to investigate alterations …

Background Adenosine triphosphate (ATP) enhances neutrophil responses, but little is
known about the role of ATP in influenza infections. Methods We used a mouse influenza …

The COVID-19 pandemic reminded us of the urgent need for new antivirals to control
emerging infectious diseases and potential future pandemics. Immunotherapy has …

Abstract In 2019, coronavirus disease 2019 (COVID-19) started a global health crisis and
was associated with high rates of depression and anxiety. Both mental disorders and COVID …