The amide functional group plays a key role in the composition of biomolecules, including
many clinically approved drugs. Bioisosterism is widely employed in the rational …

The electronic properties and relatively small size of fluorine endow it with considerable
versatility as a bioisostere and it has found application as a substitute for lone pairs of …

The applications of fluorine in drug design continue to expand, facilitated by an improved
understanding of its effects on physicochemical properties and the development of synthetic …

Recently, there has been an increasing focus on the pursuit of targets considered to be less
druggable that offer potential for development of promising new therapeutic agents for the …

Monofluoroalkenes have found wide application in organic chemistry, medicinal chemistry,
and materials science. This review summarizes the most recent advances made regarding …

A palladium-catalyzed C–H allylation of electron-deficient polyfluoroarenes with gem-
difluorinated cyclopropanes is reported. It provides a useful and facile approach to 2 …

We describe here N-phenylpyrrolidine-based inhibitors of HCV NS5A with excellent
potency, metabolic stability, and pharmacokinetics. Compounds with 2 S, 5 S …

An efficient palladium-catalyzed 2-fluoroallylation of P (O) H compounds with gem-
difluorocyclopropanes is presented. The reaction provides a variety of 2-fluoroallylic …

Abstract gem‐Heteroatom‐substituted fluoroalkenes have received little attention despite
their great potential in medicinal chemistry or in fine chemistry. Indeed, due to the electronic …

A Pd-catalyzed ring-opening sulfonylation of gem-difluorocyclopropanes is reported. This
protocol involves C–C bond cleavage, β-F elimination, and allylic coupling to form …