Neuroinflammation plays a critical role in the progression of many neurodegenerative,
neuropsychiatric and viral diseases. In neuroinflammation, activated microglia and …

Dendritic spines are tiny protrusions along dendrites, which constitute major postsynaptic
sites for excitatory synaptic transmission. These spines are highly motile and can undergo …

Dendritic spines are the postsynaptic receptive regions of most excitatory synapses, and
their morphological plasticity play a pivotal role in higher brain functions, such as learning …

Dendritic spines are actin-rich compartments that protrude from the microtubule-rich
dendritic shafts of principal neurons. Spines contain receptors and postsynaptic machinery …

Mild cognitive impairment (MCI) is considered to be an early stage in the progression of
Alzheimer's disease (AD) providing an opportunity to investigate brain pathogenesis prior to …

Alterations in synaptic protein stoichiometry may contribute to neocortical synaptic
dysfunction in Alzheimer disease (AD). Whether perturbations in synaptic protein expression …

Vascular dementia (VaD) is the second leading form of memory loss after Alzheimer's
disease (AD). Currently, there is no cure available. The etiology, pathophysiology and …

Actin filaments form contractile and protrusive structures that play central roles in many
processes such as cell migration, morphogenesis, endocytosis, and cytokinesis. During …

Neurons are the basic information-processing units of the nervous system. In fulfilling their
task, they establish a structural polarity with an axon that can be over a meter long and …

The excessive extracellular accumulation of glutamate in the ischemic brain leads to an
overactivation of glutamate receptors with consequent excitotoxic neuronal death. Neuronal …