Cancer-specificity is the key requirement for a drug or treatment regimen to be effective
against malignant disease—and has rarely been achieved adequately to date. Therefore …

Glioblastoma, the most malignant type of primary brain tumor, is one of the solid cancers
where cancer stem cells have been isolated, and studies have suggested resistance of …

Oncolytic virotherapy constitutes an upcoming alternative treatment option for a broad
spectrum of cancer entities. However, despite great research efforts, there is still only a …

ABSTRACT Herpes simplex virus 1 (HSV-1) mutants that lack the γ134. 5 gene are unable
to replicate in the central nervous system but maintain replication competence in dividing …

Malignant melanoma is a highly aggressive and drug-resistant cancer. Virotherapy is a
novel therapeutic strategy based on cancer cell lysis through selective virus replication …

Background Glioblastoma is the most frequent and most malignant primary brain tumor with
a poor prognosis. The translation of therapeutic strategies for glioblastoma from the …

Viruses have demonstrated strong potential for the therapeutic targeting of glioblastoma
stem cells (GSCs). In this study, the use of a herpes simplex virus carrying endostatin …

Glioblastoma multiforme is one of the most common human brain tumors. The tumor is
generally highly infiltrative, making it extremely difficult to treat by surgical resection or …

The use of viruses as targeted cancer therapy has shown significant promise, and the list of
oncolytic viruses continue to grow. The interest in unexplored viruses as oncolytic agents is …

Background Glioblastoma multiforme (GBM) is a relentless primary central nervous system
malignancy that remains resistant to conventional therapy despite major advances in clinical …