Gradual degeneration and loss of dopaminergic neurons in the substantia nigra, pars
compacta and subsequent reduction of dopamine levels in striatum are associated with …

Gene therapy is at the cusp of a revolution for treating a large spectrum of CNS disorders by
providing a durable therapeutic protein via a single administration. Adeno-associated virus …

Intraneuronal inclusions of misfolded α-synuclein (α-syn) and prion-like spread of the
pathologic α-syn contribute to progressive neuronal death in Parkinson's disease (PD) …

Astrocytes and microglia are brain‐resident glia that can establish harmful inflammatory
environments in disease contexts and thereby contribute to the progression of neuronal loss …

A constant metabolism and energy supply are crucial to all organs, particularly the brain.
Age-dependent neurodegenerative diseases, such as Parkinson's disease (PD), are …

Organoids are becoming particularly popular in modeling diseases that are difficult to
reproduce in animals, due to anatomical differences in the structure of a given organ. Thus …

The identification of the most efficient method for whole central nervous system targeting that
is translatable to humans and the safest route of adeno-associated virus (AAV) …

Microglia-mediated neuroinflammation is a hallmark of Parkinson's disease (PD). In the
brains of patients with PD, microglia have both neurotoxic and neuroprotective effects …

Parkinson's disease, the second most common neurodegenerative disorder worldwide, is
characterized by the accumulation of protein deposits in the dopaminergic neurons. These …

This article describes commonly used experimental and clinical biomarkers of neuronal
injury and neurodegeneration for the evaluation of neuropathology and monitoring of …