Harnessing genomic information for livestock improvement
M Georges, C Charlier, B Hayes - Nature Reviews Genetics, 2019 - nature.com
The world demand for animal-based food products is anticipated to increase by 70% by
2050. Meeting this demand in a way that has a minimal impact on the environment will …
2050. Meeting this demand in a way that has a minimal impact on the environment will …
[HTML][HTML] Invited review: A perspective on the future of genomic selection in dairy cattle
Genomic evaluation has been successfully implemented in the United States, Canada,
Great Britain, Ireland, New Zealand, Australia, France, the Netherlands, Germany, and the …
Great Britain, Ireland, New Zealand, Australia, France, the Netherlands, Germany, and the …
A multi-tissue atlas of regulatory variants in cattle
Abstract Characterization of genetic regulatory variants acting on livestock gene expression
is essential for interpreting the molecular mechanisms underlying traits of economic value …
is essential for interpreting the molecular mechanisms underlying traits of economic value …
A large-scale genome-wide association study in US Holstein cattle
Genome-wide association study (GWAS) is a powerful approach to identify genomic regions
and genetic variants associated with phenotypes. However, only limited mutual confirmation …
and genetic variants associated with phenotypes. However, only limited mutual confirmation …
New loci and neuronal pathways for resilience to heat stress in cattle
While understanding the genetic basis of heat tolerance is crucial in the context of global
warming's effect on humans, livestock, and wildlife, the specific genetic variants and …
warming's effect on humans, livestock, and wildlife, the specific genetic variants and …
Quantifying the contribution of sequence variants with regulatory and evolutionary significance to 34 bovine complex traits
Many genome variants shaping mammalian phenotype are hypothesized to regulate gene
transcription and/or to be under selection. However, most of the evidence to support this …
transcription and/or to be under selection. However, most of the evidence to support this …
Within-breed and multi-breed GWAS on imputed whole-genome sequence variants reveal candidate mutations affecting milk protein composition in dairy cattle
MP Sanchez, A Govignon-Gion, P Croiseau… - Genetics Selection …, 2017 - Springer
Background Genome-wide association studies (GWAS) were performed at the sequence
level to identify candidate mutations that affect the expression of six major milk proteins in …
level to identify candidate mutations that affect the expression of six major milk proteins in …
Pangenome-genotyped structural variation improves molecular phenotype mapping in cattle
Expression and splicing quantitative trait loci (e/sQTL) are large contributors to phenotypic
variability. Achieving sufficient statistical power for e/sQTL mapping requires large cohorts …
variability. Achieving sufficient statistical power for e/sQTL mapping requires large cohorts …
Non-additive association analysis using proxy phenotypes identifies novel cattle syndromes
EGM Reynolds, C Neeley, TJ Lopdell, M Keehan… - Nature Genetics, 2021 - nature.com
Mammalian species carry~ 100 loss-of-function variants per individual,, where~ 1–5 of these
impact essential genes and cause embryonic lethality or severe disease when homozygous …
impact essential genes and cause embryonic lethality or severe disease when homozygous …
Confirmed effects of candidate variants for milk production, udder health, and udder morphology in dairy cattle
T Tribout, P Croiseau, R Lefebvre, A Barbat… - Genetics Selection …, 2020 - Springer
Background Over the last years, genome-wide association studies (GWAS) based on
imputed whole-genome sequences (WGS) have been used to detect quantitative trait loci …
imputed whole-genome sequences (WGS) have been used to detect quantitative trait loci …