The Candida pathogenic species complex

SA Turner, G Butler - Cold Spring Harbor …, 2014 - perspectivesinmedicine.cshlp.org
Candida species are the most common causes of fungal infection. Approximately 90% of
infections are caused by five species: Candida albicans, Candida glabrata, Candida …

Candida albicans, plasticity and pathogenesis

D Poulain - Critical reviews in microbiology, 2015 - Taylor & Francis
The yeast Candida albicans has emerged as a major public health problem during the past
two decades. The spectrum of diseases caused by this species ranges from vaginal …

Genetic and phenotypic intra-species variation in Candida albicans

MP Hirakawa, DA Martinez, S Sakthikumar… - Genome …, 2015 - genome.cshlp.org
Candida albicans is a commensal fungus of the human gastrointestinal tract and a prevalent
opportunistic pathogen. To examine diversity within this species, extensive genomic and …

Gene flow contributes to diversification of the major fungal pathogen Candida albicans

J Ropars, C Maufrais, D Diogo… - Nature …, 2018 - nature.com
Elucidating population structure and levels of genetic diversity and recombination is
necessary to understand the evolution and adaptation of species. Candida albicans is the …

The 'obligate diploid' Candida albicans forms mating-competent haploids

MA Hickman, G Zeng, A Forche, MP Hirakawa… - Nature, 2013 - nature.com
Candida albicans, the most prevalent human fungal pathogen, is considered to be an
obligate diploid that carries recessive lethal mutations throughout the genome. Here we …

[HTML][HTML] Molecular epidemiology, phylogeny and evolution of Candida albicans

BA McManus, DC Coleman - Infection, Genetics and Evolution, 2014 - Elsevier
A small number of Candida species form part of the normal microbial flora of mucosal
surfaces in humans and may give rise to opportunistic infections when host defences are …

Revisiting FIS, FST, Wahlund Effects, and Null Alleles

T De Meeûs - Journal of Heredity, 2018 - academic.oup.com
Null alleles and Wahlund effects are well known causes of heterozygote deficits in empirical
population genetics studies as compared to Hardy–Weinberg genotypic expectations. Some …

[HTML][HTML] Genome plasticity in Candida albicans: A cutting-edge strategy for evolution, adaptation, and survival

IE Mba, EI Nweze, EA Eze… - Infection, Genetics and …, 2022 - Elsevier
Candida albicans is the most implicated fungal species that grows as a commensal or
opportunistic pathogen in the human host. It is associated with many life-threatening …

Assembly of a phased diploid Candida albicansgenome facilitates allele-specific measurements and provides a simple model for repeat and indel structure

D Muzzey, K Schwartz, JS Weissman, G Sherlock - Genome biology, 2013 - Springer
Background Candida albicans is a ubiquitous opportunistic fungal pathogen that afflicts
immunocompromised human hosts. With rare and transient exceptions the yeast is diploid …

Rapid Phenotypic and Genotypic Diversification After Exposure to the Oral Host Niche in Candida albicans

A Forche, G Cromie, AC Gerstein, NV Solis… - Genetics, 2018 - academic.oup.com
In vitro studies suggest that stress may generate random standing variation and that different
cellular and ploidy states may evolve more rapidly under stress. Yet this idea has not been …