Adolescent alcohol exposure persistently impacts adult neurobiology and behavior
FT Crews, RP Vetreno, MA Broadwater… - Pharmacological …, 2016 - ASPET
Adolescence is a developmental period when physical and cognitive abilities are optimized,
when social skills are consolidated, and when sexuality, adolescent behaviors, and frontal …
when social skills are consolidated, and when sexuality, adolescent behaviors, and frontal …
The role of neuroimmune signaling in alcoholism
Alcohol consumption and stress increase brain levels of known innate immune signaling
molecules. Microglia, the innate immune cells of the brain, and neurons respond to alcohol …
molecules. Microglia, the innate immune cells of the brain, and neurons respond to alcohol …
Cessation and reduction in alcohol consumption and misuse after psychedelic use
A Garcia-Romeu, AK Davis, F Erowid… - Journal of …, 2019 - journals.sagepub.com
Background: Meta-analysis of randomized studies using lysergic acid diethylamide (LSD) for
alcohol use disorder (AUD) showed large, significant effects for LSD efficacy compared to …
alcohol use disorder (AUD) showed large, significant effects for LSD efficacy compared to …
The intestinal microbiota affect central levels of brain-derived neurotropic factor and behavior in mice
P Bercik, E Denou, J Collins, W Jackson, J Lu, J Jury… - Gastroenterology, 2011 - Elsevier
BACKGROUND & AIMS: Alterations in the microbial composition of the gastrointestinal tract
(dysbiosis) are believed to contribute to inflammatory and functional bowel disorders and …
(dysbiosis) are believed to contribute to inflammatory and functional bowel disorders and …
[HTML][HTML] Neuroimmune signaling in alcohol use disorder
Alcohol use disorder (AUD) is a widespread disease with limited treatment options.
Targeting the neuroimmune system is a new avenue for developing or repurposing effective …
Targeting the neuroimmune system is a new avenue for developing or repurposing effective …
Common cellular and molecular mechanisms in obesity and drug addiction
PJ Kenny - Nature Reviews Neuroscience, 2011 - nature.com
The hedonic properties of food can stimulate feeding behaviour even when energy
requirements have been met, contributing to weight gain and obesity. Similarly, the hedonic …
requirements have been met, contributing to weight gain and obesity. Similarly, the hedonic …
Alcohol dependence as a chronic pain disorder
Dysregulation of pain neurocircuitry and neurochemistry has been increasingly recognized
as playing a critical role in a diverse spectrum of diseases including migraine, fibromyalgia …
as playing a critical role in a diverse spectrum of diseases including migraine, fibromyalgia …
The role of NFkB in drug addiction: beyond inflammation
Aims Nuclear factor kappa light chain enhancer of activated B cells (NFkB) is a ubiquitous
transcription factor well known for its role in the innate immune response. As such, NFkB is a …
transcription factor well known for its role in the innate immune response. As such, NFkB is a …
Mechanisms of neuroimmune gene induction in alcoholism
FT Crews, RP Vetreno - Psychopharmacology, 2016 - Springer
Rationale Alcoholism is a primary, chronic relapsing disease of brain reward, motivation,
memory, and related circuitry. It is characterized by an individual's continued drinking …
memory, and related circuitry. It is characterized by an individual's continued drinking …
High mobility group box 1/Toll-like receptor danger signaling increases brain neuroimmune activation in alcohol dependence
FT Crews, L Qin, D Sheedy, RP Vetreno, J Zou - Biological psychiatry, 2013 - Elsevier
BACKGROUND: Innate immune gene expression is regulated in part through high mobility
group box 1 (HMGB1), an endogenous proinflammatory cytokine, that activates multiple …
group box 1 (HMGB1), an endogenous proinflammatory cytokine, that activates multiple …