Dementia with Lewy bodies (DLB) is an age-associated neurodegenerative disorder
producing progressive cognitive decline that interferes with normal life and daily activities …

Parkinson's disease (PD), as the second most common neurodegenerative disease, is
caused by complex pathological processes and currently remains very difficult to treat. PD …

Alpha-synuclein (α-syn) is localized in cellular organelles of most neurons, but many of its
physiological functions are only partially understood. α-syn accumulation is associated with …

Alpha-synuclein (aSyn) is a central player in Parkinson's disease (PD) but the precise
molecular mechanisms underlying its pathogenicity remain unclear. It has recently been …

Parkinson's disease (PD) is the most common neurodegenerative movement disorder, and it
is characterized by the selective loss of dopaminergic (DA) neurons in the substantia nigra …

Background Neurodegenerative disorders are a group of age-associated diseases
characterized by progressive degeneration of the structure and function of the CNS. Two key …

A constant metabolism and energy supply are crucial to all organs, particularly the brain.
Age-dependent neurodegenerative diseases, such as Parkinson's disease (PD), are …

The spreading of misfolded alpha-synuclein (α-syn) protein has been observed in animal
models of Parkinson's disease (PD) and other α-synucleinopathies that mimic human PD …

Parkinson's disease (PD) is a multifactorial age-related movement disorder in which defects
of both mitochondria and the endoplasmic reticulum (ER) have been reported. The unfolded …

The loss of dopaminergic neurons of the nigrostriatal system underlies the onset of the
typical motor symptoms of Parkinson's disease (PD). Lewy bodies (LB) and Lewy neurites …