One of the major challenges in modern biology is to understand how the molecular components of a living cell operate in a highly noisy environment. What are the specific …
Living things benefit from exquisite molecular sensitivity in many of their key processes, including DNA replication, transcription and translation, chemical sensing, and …
Cells adapt to changing environments by sensing ligand concentrations using specific receptors. The accuracy of sensing is ultimately limited by the finite number of ligand …
We present a spectral-theoretic approach to time-average statistical mechanics for general, nonequilibrium initial conditions. We consider the statistics of bounded, local additive …
Cell fate decisions in the fly embryo are rapid: hunchback genes decide in minutes whether nuclei follow the anterior/posterior developmental blueprint by reading out positional …
Cells need to reliably sense external ligand concentrations to achieve various biological functions such as chemotaxis or signaling. The molecular recognition of ligands by surface …
U Dobramysl, D Holcman - Reports on Progress in Physics, 2022 - iopscience.iop.org
Computational methods are now recognized as powerful and complementary approaches in various applied sciences such as biology. These computing methods are used to explore …
We investigate the boundary between chemotaxis driven by spatial estimation of gradients and chemotaxis driven by temporal estimation. While it is well known that spatial chemotaxis …
SD Lawley, CE Miles - SIAM Journal on Applied Mathematics, 2019 - SIAM
Many biological processes are initiated when diffusing extracellular reactants reach receptors on a cell membrane. Calculating this arrival rate has therefore attracted theoretical …