A balance of Bcl-2 family proteins dictates cell survival or death, as the interactions between
these proteins regulate mitochondrial apoptotic signaling pathways. However, cancer cells …

The global incidence of cancer is rising rapidly and continues to be one of the leading
causes of death in the world. Melanoma deserves special attention since it represents one of …

Here, we report the structural optimization of a hit natural compound, 2-ME 2 (2-
methoxyestradiol), which exhibited inhibitory activity but low potency on tubulin …

The process of creating a series of 3-amino-1-aryl-8-methoxy-1 H-benzo [f] chromene-2-
carbonitriles (4a-q) involved reacting 6-methoxynaphthalen-2-ol (1), the appropriate …

In this study, a series of novel 4-Aryl-4H-chromene derivatives (D1-D31) were designed and
synthesized by integrating quinoline heterocycle to crolibulin template molecule based on …

Effective management of head and neck cancer (HNC) poses a significant challenge in the
field of oncology, due to its intricate pathophysiology and limited treatment options. The most …

Antineoplastic agents that target tubulin have shown efficacy as chemotherapeutic drugs, yet
they are often constrained by multidrug resistance (MDR) and unwanted side effects. A multi …

Aberrant angiogenesis is a hallmark of various diseases including cancers. VEGFR-2
inhibitors have been utilized as anti-angiogenic agents for several years. However …

Even though substantial progress has been made in the treatment of hepatitis C virus (HCV)
infection, viral resistance and relapse still occur in some patients and additional therapeutic …

2022-08-09 Assigned to OREGON HEALTH & SCIENCE UNIVERSITY reassignment
OREGON HEALTH & SCIENCE UNIVERSITY ASSIGNMENT OF ASSIGNORS INTEREST …