Mitochondria are key intracellular organelles involved not only in the metabolic state of the
cell, but also in several cellular functions, such as proliferation, Calcium signaling, and lipid …

Tissue transglutaminase (TG2) is a widely distributed multifunctional protein involved in a
broad range of cellular and metabolic functions carried out in a variety of cellular …

Skin cutaneous melanoma (SKCM) is the deadliest form of skin cancer due to its high
heterogeneity that drives tumor aggressiveness. Melanoma plasticity consists of two distinct …

One of the major mysteries in science is how it is possible to pack the cellular chromatin with
a total length of over 1 m, into a small sphere with a diameter of 5 mm “the nucleus”, and …

Transglutaminase type 2 (TG2) is the most ubiquitously expressed and well characterized
member of the transglutaminase family. It is a ubiquitous multifunctional enzyme implicated …

We have recently shown that type 2 transglutaminase (TG2) plays a key role in the host's
inflammatory response during bacterial infections. In this study, we investigated whether the …

Transglutaminase 2 (TG2) is a multifunctional protein widely distributed in various tissues
and involved in many physiological and pathological processes. However, its actual role in …

Abstract Tissue Transglutaminases (TGs) are crosslinking enzymes with pleiotropic
functions that have been linked to the development and progression of numerous cancers …

The cellular environment needs to be strongly regulated and the maintenance of protein
homeostasis is crucial for cell function and survival. HSF1 is the main regulator of the heat …

Cystic fibrosis (CF) is a rare autosomal recessive disease caused by mutations in the cystic
fibrosis transmembrane conductance regulator (CFTR) gene. The most common mutation is …