Abstract Primary Biliary Cholangitis (PBC) is an uncommon, chronic, cholangiopathy of
autoimmune origin and unknown etiology characterized by positive anti-mitochondrial …

Highlights•CTLA-4 is crucial for quantitative regulation of immune homeostasis and
tolerance.•LRBA plays a role in maintaining an intracellular pool of CTLA-4 in Tregs and …

Macrophages are a critical component in host immune responses against tumor. In this work
we investigated the role of forkhead box O1 (FoxO1) in the transcriptional regulation in …

The clinical benefit of CTLA-4 blockade on T cells is known, yet the impact of its expression
on cancer cells remains unaddressed. We define an immunosuppressive role for tumor …

Background Primary biliary cholangitis (PBC) is an autoimmune liver disease. The aetiology
of PBC remains unclear, and its pathogenesis is complex. Animal models are essential to …

Biallelic mutations in the human lipopolysaccharide responsive beige‐like anchor (LRBA)
gene lead to a primary immunodeficiency known as LRBA deficiency, characterized by a …

Malignant peritoneal mesothelioma (MpM), arising in the setting of local inflammation, is a
rare aggressive tumour with a poor prognosis and limited therapeutic options. The three …

During Schistosoma infection, lack of B cells results in more severe granulomas,
inflammation, and fibrosis in the liver, but the mechanisms underlying this pathology remain …

Introduction B cells are important regulators of both adaptive and innate immunity. The
normal liver contains significant numbers of B cells, and their numbers increase dramatically …

Abstract Background: Hepatocellular carcinoma (HCC), the predominant malignancy of the
digestive tract, ranks as the third most common cause of cancer-related mortality globally …