Neurodegenerative diseases (NDDs) are predicted to be the biggest health concern in this
century and the second leading cause of death by 2050. The main risk factor of these …

Discovering effective agents to slow or stop neurodegeneration is a challenging task. Over
decades, only a few drugs were approved by Food and Drug Administration (FDA) and most …

dl-3-n-Butylphthalide (NBP) has shown cytoprotective effects in animal models of stroke and
has passed clinical trials as a therapeutic drug for stroke in China. Hence, as a potential …

Alzheimer's disease (AD) is an age-related, progressive neurodegenerative disorder that
occurs gradually and results in memory, behavior, and personality changes. l-3-n …

Because of the immunogenicity and toxicity in vivo of large molecules such as lectins, the
application of these molecules is remarkably restricted in drug delivery systems. In this …

In the absence of a cure for Parkinson's disease, development of preventive medications for
this devastating disease is particularly encouraged. Dl-3-n-butylphthalide (NBP), an …

Amyotrophic lateral sclerosis (ALS) is a lethal neurodegenerative disease characterized by
progressive muscular atrophy, paralysis and bulbar symptoms. Transgenic mice over …

The average human life span in developed countries has increased to more than 80 years
following rapid breakthrough and developments in modern medicine and science, resulting …

Healthy brain aging and the problems of dementia and Alzheimer's disease (AD) are a
global concern. Beyond 60 years of age, most, if not everyone, will experience a decline in …

3-n-Butylphthalide (NBP) as well as its derivatives and analogues (NBPs), in racemic or
enantiomerically pure forms, possess potent and diverse pharmacological properties and …