Statins, which are widely used to treat hypercholesterolemia, have anti-inflammatory and
anti-oxidant effects. These are thought to be responsible for the potential effects of statins on …

Exogenous administration of inflammatory stimuli to humans and laboratory animals and
chronic endogenous inflammatory states lead to motivational deficits and ultimately …

Background In epidemiological studies, statins appear to benefit mood, and there are now
some randomized controlled trials examining the efficacy of statins. However, the role of …

Background: Depression is a leading cause of disability, burdened by high levels of non-
response to conventional antidepressants. Novel therapeutic strategies targeting non …

Importance Depression is associated with increased inflammation, which may precede its
onset, especially in older people. Some preclinical data suggest potential antidepressant …

Objective To investigate whether continued use of non‐aspirin NSAID, low‐dose aspirin,
high‐dose aspirin, statins, allopurinol and angiotensin agents decreases the rate of incident …

Neuroinflammation is recognised as one of the potential mechanisms mediating the onset of
a broad range of psychiatric disorders and may contribute to nonresponsiveness to current …

Given the moderate efficacy of the currently available antidepressants (ADs) in the treatment
of major depressive disorder (MDD), the identification of agents that are both able to …

Statins are widely accepted as first-choice agents for the prevention of lipid-related
cardiovascular diseases. These drugs have both anti-inflammatory and anti-oxidant …

Growing evidence supports a mutual relationship between inflammation and major
depression. A variety of mechanisms are outlined, indicating how inflammation may be …