Current and emerging treatment options in primary mediastinal B-cell lymphoma

B Fakhri, W Ai - Therapeutic Advances in Hematology, 2021 - journals.sagepub.com
Previously considered a subtype of diffuse large B-cell lymphoma (DLBCL), primary
mediastinal B-cell lymphoma (PMBCL) is now recognized by the World Health Organization …

Rituximab: 13 open questions after 20 years of clinical use

F Pavanello, E Zucca, M Ghielmini - Cancer treatment reviews, 2017 - Elsevier
Rituximab improved the prognosis of all B-cell derived lymphoproliferative diseases, but
despite 20 years of intensive use, it remains a drug with a number of still obscure …

[HTML][HTML] Central nervous system relapse of diffuse large B-cell lymphoma in the rituximab era: results of the UK NCRI R-CHOP-14 versus 21 trial

M Gleeson, N Counsell, D Cunningham, N Chadwick… - Annals of …, 2017 - Elsevier
Background Central nervous system (CNS) relapse of diffuse large B-cell lymphoma
(DLBCL) is associated with a dismal prognosis. Here, we report an analysis of CNS relapse …

Outcomes after first-line immunochemotherapy for primary mediastinal B-cell lymphoma: a LYSA study

V Camus, C Rossi, P Sesques, J Lequesne… - Blood …, 2021 - ashpublications.org
Primary mediastinal B-cell lymphoma (PMBL) is a rare type of aggressive lymphoma
typically affecting young female patients. The first-line standard of care remains debated. We …

Identification of very low-risk subgroups of patients with primary mediastinal large B-cell lymphoma treated with R-CHOP

TP Vassilakopoulos, M Michail, S Papageorgiou… - The …, 2021 - academic.oup.com
Background R-CHOP can cure approximately 75% of patients with primary mediastinal large
B-cell lymphoma (PMLBCL), but prognostic factors have not been sufficiently evaluated yet …

Primary mediastinal large B-cell lymphoma

A Dabrowska-Iwanicka, JA Walewski - Current hematologic malignancy …, 2014 - Springer
Primary mediastinal B-cell lymphoma (PMBCL) is a relatively rare lymphoma subtype
affecting mainly young adults. Its molecular signature and clinical features resemble …

Primary mediastinal large B-cell lymphoma

VR Bhatt, R Mourya, R Shrestha, JO Armitage - Cancer Treatment Reviews, 2015 - Elsevier
The management of primary mediastinal large B-cell lymphoma (PMBCL) requires a
balance between optimizing chances of cure and reducing risk of long-term toxicities. The …

Primary mediastinal B-cell lymphoma: novel precision therapies and future directions

H Chen, T Pan, Y He, R Zeng, Y Li, L Yi, H Zang… - Frontiers in …, 2021 - frontiersin.org
Primary mediastinal large B-cell lymphoma (PMBCL) is a distinct clinicopathologic disease
from other types of diffuse large B-cell lymphoma (DLBCL) with unique prognostic features …

Positron emission tomography after response to rituximab-CHOP in primary mediastinal large B-cell lymphoma: impact on outcomes and radiotherapy strategies

TP Vassilakopoulos, SG Papageorgiou… - Annals of …, 2021 - Springer
Abstract End-of-treatment (EoT) PET/CT is used as a guide to omit radiotherapy (RT)
patients with primary mediastinal large B-cell lymphoma (PMBCL). We present the mature …

Risk of CNS dissemination in extranodal lymphomas

AJM Ferreri - The Lancet Oncology, 2014 - thelancet.com
Extranodal lymphomas constitute a heterogeneous group of malignancies, accounting for
roughly 60% of all non-Hodgkin lymphomas. The extranodal organ where lymphomas arise …