Cancer is one of the main causes of death worldwide. To date, and despite the advances in
conventional treatment options, therapy in cancer is still far from optimal due to the non …

Hypoxia is an integral component of the tumor microenvironment. Either as chronic or
cycling hypoxia, it exerts a similar effect on cancer processes by activating hypoxia-inducible …

Fluorouracil (5-FU) has become one of the most widely employed antimetabolite
chemotherapeutic agents in recent decades. It is considered a first line antineoplastic agent …

The cancer stem cell (CSC) concept stands for undifferentiated tumor cells with the ability to
initiate heterogeneous tumors. It is also relevant in metastasis and can explain how …

In the late 70's, the discovery of the restriction enzymes made possible the biological
production of functional proteins by recombinant DNA technologies, a fact that largely …

The cancer stem cell (CSC) concept emerged from the recognition of inherent tumor
heterogeneity and suggests that within a given tumor, in analogy to normal tissues, there …

Among inorganic materials, divalent cations modulate thousands of physiological processes
that support life. Their roles in protein assembly and aggregation are less known, although …

Colorectal cancer (CRC) remains the third cause of cancer-related mortality in Western
countries, metastases are the main cause of death. CRC treatment remains limited by …

Background: Metastasis is the major reason for the high mortality of colorectal cancer (CRC).
However, the molecular mechanism underlying CRC metastasis remains unclear. Here, we …

Pancreatic ductal adenocarcinoma (PDAC) tumors are characterized by a desmoplastic
reaction resulting in dense deposition of collagen that is known to promote cancer …