In his seminal work, 1 Rolf Huisgen defined 1, 3-dipolar cycloadditions as “1, 3-Dipole, abc,
must be defined, such that atom a posseses an electron sextet, that is, an incomplete …

It was in 1963 that Huisgen laid out the classification of 1, 3-dipoles and the concepts for 1, 3-
dipolar cycloaddition reactions, although it was not until 1976 that the first intramolecular 1, 3 …

Reactions that utilize addition of active C− H nucleophiles to C X bonds represent some of
the most fundamental carbon− carbon bond-forming processes in organic chemistry. Of …

1, 3-Dipolar cycloaddition reactions are fundamental processes in organic chemistry, 1 and
their asymmetric version offers a powerful and reliable synthetic methodology to access five …

Heterocyclic synthesis involving transition metal complexes has become of common use in
the past decade because a transition-metal-catalyzed reaction can directly build …

Electrophilic indoles having two electron‐withdrawing groups undergo nucleophilic attack at
C2 and electrophilic functionalization at C3. This is the first enantioselective formal [3+ 2] …

The novel C 2-symmetric bis (imidazolidine) pyridine (PyBidine) ligand was easily
synthesized in a single condensation of 2, 6-pyridyl aldehyde and optically active (S, S) …

Hepatitis C virus (HCV) infection is the major cause of chronic liver disease, leading to
cirrhosis and hepatocellular carcinoma, which affects more than 170 million people …

(Chemical Equation Presented) Electronic properties of the ligands switch the
diastereoselectivity in the Cu-catalyzed 1, 3-dipolar cycloaddition of azomethine ylides to …

The first total synthesis of the biologically significant bis-indole alkaloid dragmacidin D (5)
has been achieved. Thermal and electronic modulation provides the key for a series of …