The incidence and mortality rate of cancer has been quickly increasing in the past decades.
At present, cancer has become the leading cause of death worldwide. Most of the cancers …

Long noncoding RNAs are involved in epigenetic gene modification, including binding to the
chromatin rearrangement complex in pre-transcriptional regulation and to gene promoters in …

Non coding RNAs (ncRNAs) have emerged as regulators of human carcinogenesis by
affecting the expression of key tumor suppressor genes and oncogenes. They are divided …

In various human cancers, long non-coding RNAs (lncRNAs), a novel class of RNAs longer
than 200 nucleotides without protein-coding potential, are implicated in a variety of …

Simple Summary Research on leukemia has often led to novel approaches in clinical
practice. Cytogenetical and molecular markers have been introduced in treatment protocols …

The majority of the human genome is comprised of non-protein-coding genes, but the
relevance of non-coding RNAs in complex diseases has yet to be fully elucidated. One class …

Many patients with acute myeloid leukemia (AML) experience poor outcomes following
traditional high-dose chemotherapies and complete remission rates remain suboptimal …

NGS technologies and bioinformatics tools allow the rapid identification of chimeric
transcripts in cancer. More than 40,000 fusions are so far reported in the literature; however …

Human endogenous retroviruses (HERVs) are LTR retrotransposons that are present in the
human genome. Among them, members of the HERV-K (HML-2) group are suspected to …

Long non-coding RNA (LncRNA) is recently linked to various types of cancers, CCAT and
PVT1 are two LncRNAs linked to t (8; 21) associated Acute Myeloid Leukemia, the interplay …