Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets

B Wang, L Wu, J Chen, L Dong, C Chen… - Signal transduction and …, 2021 - nature.com
The arachidonic acid (AA) pathway plays a key role in cardiovascular biology,
carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified …

Cellular stress responses in radiotherapy

W Kim, S Lee, D Seo, D Kim, K Kim, EG Kim, JH Kang… - Cells, 2019 - mdpi.com
Radiotherapy is one of the major cancer treatment strategies. Exposure to penetrating
radiation causes cellular stress, directly or indirectly, due to the generation of reactive …

Immune system in cancer radiotherapy: Resistance mechanisms and therapy perspectives

K Mortezaee, M Najafi - Critical reviews in oncology/hematology, 2021 - Elsevier
Radiotherapy is a common modality for more than half of cancer patients. Classically,
radiation is known as a strategy to kill cancer cells via direct interaction with DNA or …

Arachidonic acid metabolism in health and disease

Y Zhang, Y Liu, J Sun, W Zhang, Z Guo, Q Ma - MedComm, 2023 - Wiley Online Library
Arachidonic acid (AA), an n‐6 essential fatty acid, is a major component of mammalian cells
and can be released by phospholipase A2. Accumulating evidence indicates that AA plays …

Role of metabolic reprogramming in epithelial–mesenchymal transition (EMT)

H Kang, H Kim, S Lee, HS Youn, BH Youn - International Journal of …, 2019 - mdpi.com
Activation of epithelial–mesenchymal transition (EMT) is thought to be an essential step for
cancer metastasis. Tumor cells undergo EMT in response to a diverse range of extra-and …

Targeted delivery of nano-radiosensitizers for tumor radiotherapy

S Shi, H Zhong, Y Zhang, Q Mei - Coordination Chemistry Reviews, 2024 - Elsevier
Radiotherapy is a major tumor treatment approach in clinical, however, the use of high-dose
X-rays during therapy inevitably causes damage to nearby healthy tissues, greatly reducing …

Pathomechanisms and therapeutic opportunities in radiation-induced heart disease: from bench to bedside

M Sárközy, Z Varga, R Gáspár, G Szűcs… - Clinical Research in …, 2021 - Springer
Cancer management has undergone significant improvements, which led to increased long-
term survival rates among cancer patients. Radiotherapy (RT) has an important role in the …

COX 2-inhibitors; a thorough and updated survey into combinational therapies in cancers

P Rodrigues, H Bangali, A Hammoud, YF Mustafa… - Medical Oncology, 2024 - Springer
Cyclooxygenase (COX) enzymes are pivotal in inflammation and cancer development. COX-
2, in particular, has been implicated in tumor growth, angiogenesis, and immune evasion …

Radioresistance of human cancers: clinical implications of genetic expression signatures

S de Mey, I Dufait, M De Ridder - Frontiers in oncology, 2021 - frontiersin.org
Although radiotherapy is given to more than 50% of cancer patients, little progress has been
made in identifying optimal radiotherapy-drug combinations to improve treatment efficacy …

Carboranes as unique pharmacophores in antitumor medicinal chemistry

Y Chen, F Du, L Tang, J Xu, Y Zhao, X Wu, M Li… - Molecular Therapy …, 2022 - cell.com
Carborane is a carbon-boron molecular cluster that can be viewed as a 3D analog of
benzene. It features special physical and chemical properties, and thus has the potential to …