Intranasal COVID-19 vaccines: From bench to bed

A Alu, L Chen, H Lei, Y Wei, X Tian, X Wei - EBioMedicine, 2022 - thelancet.com
Currently licensed COVID-19 vaccines are all designed for intramuscular (IM) immunization.
However, vaccination today failed to prevent the virus infection through the upper respiratory …

Viruses as biomaterials

T Yang, Y Chen, Y Xu, X Liu, M Yang, C Mao - Materials Science and …, 2023 - Elsevier
Viruses lacking the capacity to infect mammals exhibit minimal toxicity, good
biocompatibility, and well-defined structures. As self-organized biomolecular assemblies …

Process development for newcastle disease virus-vectored vaccines in serum-free vero cell suspension cultures

JPC Fulber, O Farnós, S Kiesslich, Z Yang, S Dash… - Vaccines, 2021 - mdpi.com
The ongoing COVID-19 pandemic drew global attention to infectious diseases, attracting
numerous resources for development of pandemic preparedness plans and vaccine …

Development and scalable production of Newcastle disease virus-vectored vaccines for human and veterinary use

JPC Fulber, AA Kamen - Viruses, 2022 - mdpi.com
The COVID-19 pandemic has highlighted the need for efficient vaccine platforms that can
rapidly be developed and manufactured on a large scale to immunize the population against …

Current progress in pharmacokinetic studies of vaccines: Impact of carrier, ADME and its modulation on immune responses

SK Jha, M Imran, LA Jha, N Hasan, VK Panthi… - Environmental …, 2023 - Elsevier
The lack of knowledge about the absorption, distribution, metabolism, and excretion (ADME)
of vaccines makes biopharmaceutical optimization difficult. This was shown during the …

[HTML][HTML] Advantages and challenges of Newcastle disease virus as a vector for respiratory mucosal vaccines

RL de Swart, GA Belov - Current Opinion in Virology, 2023 - Elsevier
Highlights•NDV platform allows rapid development of live vaccines against emerging
pathogens.•NDV vectors are stable, safe, easy to propagate, and administer.•Improved …

Intranasal SARS-CoV-2 Omicron variant vaccines elicit humoral and cellular mucosal immunity in female mice

S Slamanig, I González-Domínguez, LA Chang… - …, 2024 - thelancet.com
Background In order to prevent the emergence and spread of future variants of concern of
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), developing vaccines …

Intranasal vaccination with an NDV-vectored SARS-CoV-2 vaccine protects against Delta and Omicron challenges

BM Warner, JGE Yates, R Vendramelli, T Truong… - npj Vaccines, 2024 - nature.com
The rapid development and deployment of vaccines following the emergence of severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been estimated to have saved …

Newcastle Disease Virus (NDV)-based vaccine candidate against SARS-CoV-2 Omicron by intranasal immunization

QY Zhang, HQ Zhang, YN Zhang, ZR Zhang, XD Li… - Antiviral Research, 2023 - Elsevier
Despite global vaccination efforts, severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) continues to evolve and spread globally. Currently, the development of affordable …

[HTML][HTML] Intranasal administration of a live-attenuated recombinant newcastle disease virus expressing the SARS-CoV-2 Spike protein induces high neutralizing …

RL de Swart, OS de Leeuw, N Oreshkova… - vaccine, 2022 - Elsevier
The emergence of SARS-CoV-2 in December 2019 resulted in the COVID-19 pandemic.
Recurring disease outbreaks repeatedly overloaded the public health sector and severely …