Nutrition and genetics in NAFLD: the perfect binomium

M Meroni, M Longo, A Rustichelli… - International Journal of …, 2020 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) represents a global healthcare burden since it is
epidemiologically related to obesity, type 2 diabetes (T2D) and Metabolic Syndrome (MetS) …

Effects of alpha lipoic acid on metabolic syndrome: a comprehensive review

N Najafi, S Mehri… - Phytotherapy …, 2022 - Wiley Online Library
Metabolic syndrome (MetS) is a multifactorial disease with medical conditions such as
hypertension, diabetes, obesity, dyslipidemia, and insulin resistance. Alpha‐lipoic acid (α …

Safety evaluation of α-lipoic acid supplementation: A systematic review and meta-analysis of randomized placebo-controlled clinical studies

F Fogacci, M Rizzo, C Krogager, C Kennedy… - Antioxidants, 2020 - mdpi.com
Alpha-lipoic acid (ALA) is a natural short-chain fatty acid that has attracted great attention in
recent years as an antioxidant molecule. However, some concerns have been recently …

ACVR1 function in health and disease

JA Valer, C Sánchez-de-Diego, C Pimenta-Lopes… - Cells, 2019 - mdpi.com
Activin A receptor type I (ACVR1) encodes for a bone morphogenetic protein type I receptor
of the TGFβ receptor superfamily. It is involved in a wide variety of biological processes …

Alpha-lipoic acid activates AMPK to protect against oxidative stress and apoptosis in rats with diabetic peripheral neuropathy

T Zhang, D Zhang, Z Zhang, J Tian, J An, W Zhang… - Hormones, 2023 - Springer
Purpose To investigate the AMPK pathway–mediated effect of alpha-lipoic acid (ALA) on the
dorsal root ganglia (DRGs) of rats with diabetic peripheral neuropathy (DPN) and to attempt …

[HTML][HTML] Bioactive compounds in childhood obesity and associated metabolic complications: Current evidence, controversies and perspectives

G Fiore, MC Pascuzzi, E Di Profio, A Corsello… - Pharmacological …, 2023 - Elsevier
Obesity represents the most frequent chronic disease among children worldwide, with a
significant global burden on society. Metabolically unhealthy obesity (MUO) can affect …

Clinical effectiveness of α-lipoic acid, myo-inositol and propolis supplementation on metabolic profiles and liver function in obese patients with NAFLD: A randomized …

H Tutunchi, S Arefhosseini… - Clinical Nutrition …, 2023 - Elsevier
Background To compare the effects of α-lipoic acid (ALA), myo-inositol (MI) and propolis
supplementation on metabolic parameters and liver function in obese patients with non …

Hepatoprotective potential of alpha-lipoic acid against gliclazide-induced liver injury in high-glucose-exposed human liver cells and experimental type 2 diabetic rats

GJ Dugbartey, S Atule, KK Alornyo, I Adams - Biochemical Pharmacology, 2024 - Elsevier
Growing clinical evidence shows that sulfonylurea therapy for patients with type 2 diabetic
mellitus (T2DM) contributes to progressive worsening of their liver. The present study …

Targeting hepatic sulfane sulfur/hydrogen sulfide signaling pathway with α-lipoic acid to prevent diabetes-induced liver injury via upregulating hepatic CSE/3-MST …

GJ Dugbartey, KK Alornyo, I Adams, S Atule… - Diabetology & metabolic …, 2022 - Springer
Background Diabetes-induced liver injury is a complication of diabetes mellitus of which
there are no approved drugs for effective treatment or prevention. This study investigates …

The effect of hydroxy citric acid supplementation with calorie-restricted diet on metabolic, atherogenic and inflammatory biomarkers in women with non-alcoholic fatty …

S Arefhosseini, H Tutunchi, S Nomi-Golzar… - Food & Function, 2022 - pubs.rsc.org
The objective of the present study was to examine the effects of hydroxy citric acid (HCA)
extracts from Garcinia cambogia on metabolic, atherogenic and inflammatory biomarkers in …