Summary Hypoxia-inducible factor (HIF), a central regulator for detecting and adapting to
cellular oxygen levels, transcriptionally activates genes modulating oxygen homeostasis …

Hypoxia is an essential hallmark of several serious diseases such as cardiovascular and
metabolic disorders and cancer. A decline in the tissue oxygen level induces hypoxic …

Collagen is one of the most useful biopolymers because of its low immunogenicity and
biocompatibility. The biomedical potential of natural collagen is limited by its poor …

Exosomes are small extracellular vesicles that are secreted by almost all types of cells and
exist in almost all extracellular spaces. As an important mediator of intercellular …

Complexity and difficulties in wound management are pressing concerns that affect patients'
quality of life and may result in tissue infection, necrosis, and loss of local and systemic …

The overall structure and architecture of the extracellular matrix undergo dramatic alterations
in composition, form, and functionality over time. The stochasticity begins during …

Each year, millions of individuals suffer from a non-healing wound, abnormal scarring, or
injuries accompanied by an infection. For these cases, scientists are searching for new …

Background Lysyl oxidase-like 4 (LOXL4) has been found to be dysregulated in several
human malignancies, including hepatocellular carcinoma (HCC). However, the role of …

Extracellular vesicles (EV) are small plasma membrane-derived particles released into the
extracellular space by virtually all cell types. Recently, EV have received increased interest …

Hypoxia is a key feature of solid tumors, associated with disease aggressiveness and poor
outcome. Besides undergoing broad intracellular molecular and metabolic adaptations …