Ubiquitination is a highly conserved and fundamental posttranslational modification (PTM) in
all eukaryotes regulating thousands of proteins. The RING (really interesting new gene) …

The innate immune system protects the host from external pathogens and internal damage
in various ways. The cGAS-STING signaling pathway, comprised of cyclic GMP-AMP …

Inflammation is closely associated with obesity and related metabolic disorders. However, its
origin during obesity is largely unknown. Here, we report that ubiquitin-conjugating enzyme …

The cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS) plays a critical role in antiviral
immunity and autoimmunity. The activity and stability of cGAS are fine-tuned by post …

SIPR α on macrophages binds with CD47 to resist proengulfment signals, but how the
downstream signal of SIPR α controls tumor-infiltrating macrophages (TIMs) is still poorly …

Multivesicular bodies (MVBs) fuse with not only the plasma membranes to release
extracellular vesicles (EVs) but also lysosomes for degradation. Rab7 participates in the …

NEDD8 (Neural precursor cell expressed developmentally downregulated protein 8) is an
ubiquitin-like protein that is covalently attached to a lysine residue of a protein substrate …

Innate immune mechanisms initiate immune responses via pattern-recognition receptors
(PRRs). Cyclic GMP-AMP synthase (cGAS), a member of the PRRs, senses diverse …

As a key dsDNA recognition receptor, cyclic guanosine monophosphate (GMP)-AMP
synthase (cGAS) plays a vital role in innate immune responses. Activated cGAS, by sensing …

ABSTRACT STING1 (stimulator of interferon response cGAMP interactor 1), the pivotal
adaptor protein of CGAS (cyclic GMP-AMP synthase)-STING1 signaling, is critical for type I …