The fate of leydig cells in men with spermatogenic failure

D Adamczewska, J Słowikowska-Hilczer… - Life, 2022 - mdpi.com
The steroidogenic cells in the testicle, Leydig cells, located in the interstitial compartment,
play a vital role in male reproductive tract development, maintenance of proper …

Unified single-cell analysis of testis gene regulation and pathology in five mouse strains

M Jung, D Wells, J Rusch, S Ahmad, J Marchini… - Elife, 2019 - elifesciences.org
To fully exploit the potential of single-cell functional genomics in the study of development
and disease, robust methods are needed to simplify the analysis of data across samples …

Molecular mechanisms of cellular dysfunction in testes from men with non-obstructive azoospermia

A Piechka, S Sparanese, L Witherspoon… - Nature Reviews …, 2024 - nature.com
Male factor infertility affects 50% of infertile couples worldwide; the most severe form, non-
obstructive azoospermia (NOA), affects 10–15% of infertile males. Treatment for individuals …

Gut Endotoxin Leading to a Decline IN Gonadal function (GELDING)-a novel theory for the development of late onset hypogonadism in obese men

K Tremellen - Basic and clinical andrology, 2016 - Springer
Obesity is an increasing public health problem, with two-thirds of the adult population in
many Western countries now being either overweight or obese. Male obesity is associated …

Evaluating the effect of silver nanoparticles on testes of adult albino rats (histological, immunohistochemical and biochemical study)

SM Ahmed, SA Abdelrahman, SM Shalaby - Journal of molecular histology, 2017 - Springer
Silver nanoparticles (AgNPs) are widely used in medicine, however, they have toxic impacts
on different organs. AgNPs distribution to the testes was reported, so, we aimed to study the …

Effects of superparamagnetic iron oxide nanoparticles (SPIONS) testicular injection on Leydig cell function and sperm production in a murine model

FS Ferraz, G de PF Dantas, JLP Coimbra… - Reproductive …, 2024 - Elsevier
In the domain of medical advancement, nanotechnology plays a pivotal role, especially in
the synthesis of biocompatible materials for therapeutic use. Superparamagnetic Iron Oxide …

Dynamics, ultrastructure and gene expression of human in vitro organized testis cells from testicular sperm extraction biopsies

K von Kopylow, W Schulze, A Salzbrunn… - MHR: Basic science …, 2018 - academic.oup.com
STUDY QUESTION Is it possible to induce in vitro reorganization of primary human testis
cells from testicular sperm extraction (TESE) biopsies, maintain their long-term cultivation in …

Tumor-associated macrophages derived from cancer stem cells

A Osman, M Oze, SM Afify, G Hassan, ELG Samah… - Acta …, 2020 - Elsevier
Macrophages are the most abundant immune cells in the microenvironment of solid tumors.
The present study displayed histological and immunohistochemical analyses of a malignant …

Prepubertal onset of obesity negatively impacts on testicular steroidogenesis in rats

IV Wagner, N Klöting, N Atanassova, I Savchuk… - Molecular and cellular …, 2016 - Elsevier
Obesity is a global health problem and impacts negatively on levels of testosterone and
quality of sperm production. At present little is known about mechanisms that attenuate …

SARS-CoV-2 infects, replicates, elevates angiotensin II and activates immune cells in human testes

GMJ Costa, SMSN Lacerda, AFA Figueiredo, NT Wnuk… - MedRxiv, 2022 - medrxiv.org
Although much has been published since the first cases of COVID-19, there remain
unanswered questions regarding SARS-CoV-2 impact on testes and the potential …