The Interferon regulatory factors (IRFs) are a family of transcription factors that play pivotal
roles in many aspects of the immune response, including immune cell development and …

The traditional view of the adult brain as a static organ has changed in the past three
decades, with the emergence of evidence that it remains plastic and has some regenerative …

Background Necroptosis is emerging as a new target for cancer immunotherapy as it is now
recognized as a form of cell death that increases tumor immunogenicity, which would be …

The mononuclear phagocytes control the body homeostasis through the involvement in
resolving tissue injury and further wound healing. Indeed, local tissue microenvironmental …

The incidence of adverse effects and pathogen resistance encountered with small molecule
antibiotics is increasing. As such, there is mounting focus on immunogene therapy to …

Inflammation is set off when innate immune cells detect infection or tissue injury. Tight
control of the severity, duration, and location of inflammation is an absolute requirement for …

Macrophages are key innate immune cells in the tumor microenvironment (TME) that
regulate primary tumor growth, vascularization, metastatic spread and tumor response to …

TRIM protein family is an evolutionarily conserved gene family implicated in a number of
critical processes including inflammation, immunity, antiviral and cancer. In an effort to …

Macrophages respond to noxious stimuli and contribute to inflammatory responses by
eliminating pathogens or damaged tissue and maintaining homeostasis. Response to …

The mononuclear phagocyte system regulates tissue homeostasis as well as all phases of
tissue injury and repair. To do so changing tissue environments alter the phenotype of tissue …