The inner ear and the epibranchial ganglia constitute much of the sensory system in the
caudal vertebrate head. The inner ear consists of mechanosensory hair cells, their neurons …

Vision, olfaction, hearing, and balance are mediated by receptors that reside in specialized
sensory epithelial organs. Age-related degeneration of the photoreceptors in the retina and …

Members of the fibroblast growth factor (FGF) family have myriad functions during
development of both non-vertebrate and vertebrate organisms. One of these family …

Objective To analyze the prevalence of FGFR1, FGF8, and FGF17 mutations in a Chinese
cohort with idiopathic hypogonadotropic hypogonadism (IHH) and to characterize the …

Vertebrate embryogenesis gives rise to all cell types of an organism through the
development of many unique lineages derived from the three primordial germ layers. The …

Multiple signaling molecules, including Fibroblast Growth Factor (FGF) and Wnt, induce two
patches of ectoderm on either side of the hindbrain to form the progenitor cell population for …

Despite the vital importance of Fgf for otic induction, previous attempts to study otic induction
through Fgf misexpression have yielded widely varying and contradictory results. There are …

Background In multiple vertebrate organisms, including chick, Xenopus, and zebrafish,
Fibroblast Growth Factor (FGF) and Wnt signaling cooperate during formation of the otic …

Neural crest (NC) is the primitive neural structure in embryonic stage, which develops from
ectodermal neural plate cells and epithelial cells. When the neural fold forms into neural …

Progress in understanding mechanisms of inner ear development has been remarkably
rapid in recent years. The research community has benefited from the availability of several …