ABCA7 deficiency causes neuronal dysregulation by altering mitochondrial lipid metabolism

K Kawatani, ML Holm, SC Starling, YA Martens… - Molecular …, 2023 - nature.com
ABCA7 loss-of-function variants are associated with increased risk of Alzheimer's disease
(AD). Using ABCA7 knockout human iPSC models generated with CRISPR/Cas9, we …

Methionine deficiency affects myogenesis and muscle macronutrient metabolism in juvenile turbot Scophthalmus maximus

Z Sui, X Wang, Y Sun, H Zhou, C Liu, K Mai, G He - Aquaculture, 2024 - Elsevier
The study was aimed to explore the impacts of dietary methionine availability on muscle
growth and macronutrient metabolism in turbot. Based the optimal dietary methionine …

Comparative transcriptomics and host-specific parasite gene expression profiles inform on drivers of proliferative kidney disease

M Faber, S Shaw, S Yoon, E de Paiva Alves, B Wang… - Scientific Reports, 2021 - nature.com
The myxozoan parasite, Tetracapsuloides bryosalmonae has a two-host life cycle
alternating between freshwater bryozoans and salmonid fish. Infected fish can develop …

Monoacylglycerol acyltransferase 1 knockdown exacerbates hepatic ischemia/reperfusion injury in mice with hepatic steatosis

KHH Liss, SE Ek, AJ Lutkewitte, TA Pietka… - Liver …, 2021 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) is becoming the most common indication for liver
transplantation. The growing prevalence of NAFLD not only increases the demand for liver …

[HTML][HTML] Fine-tuning of postprandial responses via feeding frequency and leucine supplementation affects dietary performance in turbot (Scophthalmus maximus L.)

N Wang, X Zhang, C Liu, X Wang, H Zhou, K Mai… - The Journal of …, 2021 - Elsevier
Background Feeding-induced cell signaling and metabolic responses affect utilization of
dietary nutrients but are rarely taken advantage of to improve animal nutrition. Objectives We …

Dynamic changes in the mouse hepatic lipidome following warm ischemia reperfusion injury

KHH Liss, M Mousa, S Bucha, A Lutkewitte… - Scientific reports, 2024 - nature.com
Liver failure secondary to metabolic dysfunction-associated steatotic liver disease (MASLD)
has become the most common cause for liver transplantation in many parts of the world …

Characterization of Metabolite Compositions in Wild and Farmed Red Sea Bream (Pagrus major) Using Mass Spectrometry Imaging

N Goto-Inoue, T Sato, M Morisasa… - Journal of agricultural …, 2019 - ACS Publications
Nutritional profiles and consumer preferences differ between wild and farmed fish, and
identification of fish sources can be difficult. We analyzed the metabolite molecules of wild …

EPA and DHA promote cell proliferation and enhance activity of the Akt-TOR-S6K anabolic signaling pathway in primary muscle cells of turbot (Scophthalmus …

Y Gao, C Liu, X Wang, H Zhou, K Mai, G He - Fish Physiology and …, 2024 - Springer
Fish growth and health are predominantly governed by dietary nutrient supply. Although the
beneficial effects of omega-3 polyunsaturated fatty acids supplementation have been shown …

Transcriptome-based nutrigenomics analysis reveals the roles of dietary taurine in the muscle growth of juvenile turbot (Scophthalmus maximus)

H Hays, Z Gu, K Mai, W Zhang - … and Physiology Part D: Genomics and …, 2023 - Elsevier
The present study explored transcriptomics and gene regulation variations in the muscle of
turbot fed with dietary taurine. A 70-day feeding trial was conducted using turbot (initial body …

[HTML][HTML] Oleic acid stimulation of amino acid uptake in primary human trophoblast cells is mediated by phosphatidic acid and mTOR signaling

E Silva, V Ferchaud‐Roucher, A Kramer… - FASEB …, 2024 - ncbi.nlm.nih.gov
Normal fetal development is critically dependent on optimal nutrient supply by the placenta,
and placental amino acid transport has been demonstrated to be positively associated with …