Ageing is a complex process that negatively impacts the development of the immune system
and its ability to function. The mechanisms that underlie these age‐related defects are broad …

Epigenetic “clocks” can now surpass chronological age in accuracy for estimating biological
age. Here, we use four such age estimators to show that epigenetic aging can be reversed …

The circadian rhythm orchestrates many cellular functions, such as cell division, cell
migration, metabolism and numerous intracellular biological processes. The physiological …

The mechanisms of CD4+ T-cell count decline, the hallmark of HIV disease progression, and
its relationship to elevated levels of immune activation are not fully understood. Massive …

Growth hormone (GH) is an underappreciated but important regulator of T cell development
that can reverse age-related declines in thymopoiesis in rodents. Here, we report findings of …

Toll-like receptors (TLRs) play a key role in pathogen recognition and regulation of the
innate and adaptive immune responses. Although TLR expression and signaling have been …

Among the mechanisms implicated in the tumor-promoting effects of obesity, signaling by
insulin-like growth factor-I (IGF-I) and insulin has received considerable attention. However …

Growth hormone (GH) is a classic pituitary-derived hormone crucial to body growth and
metabolism. In the pituitary gland, GH production is stimulated by GH-releasing hormone …

We recently reported that human bone marrow hematopoietic CD34+ progenitors express
functional Toll‐like receptors (TLR) and can differentiate into myeloid cells just by stimulation …

The thymus constitutes the primary lymphoid organ for the generation of T cells. Its function
is particularly susceptible to various negative influences ranging from age-related involution …