The transcription factor Sox9 was first discovered in patients with campomelic dysplasia, a
haploinsufficiency disorder with skeletal deformities caused by dysregulation of Sox9 …

The mammalian respiratory system—the trachea and the lungs—arises from the anterior
foregut through a sequence of morphogenetic events involving reciprocal endodermal …

Recapitulation of lung development from human pluripotent stem cells (hPSCs) in three
dimensions (3D) would allow deeper insight into human development, as well as the …

INTRODUCTION The alveolar region of the lung develops in a period that spans the late
embryonic and early postnatal stages of life. An intricate series of events—including cellular …

A goal of single-cell genome-wide profiling is to reconstruct dynamic transitions during cell
differentiation, disease onset and drug response. Single-cell assays have recently been …

Summary Two populations of Nkx2-1+ progenitors in the developing foregut endoderm give
rise to the entire postnatal lung and thyroid epithelium, but little is known about these cells …

The current study aimed to understand the developmental mechanisms regulating bud tip
progenitor cells in the human fetal lung, which are present during branching …

Developmental lung biology is a field that has the potential for significant human impact:
lung disease at the extremes of age continues to cause major morbidity and mortality …

Deriving lung progenitors from patient-specific pluripotent cells is a key step in producing
differentiated lung epithelium for disease modeling and transplantation. By mimicking the …

The vertebrate lung is elegantly patterned to carry out gas exchange and host defense.
Similar to other organ systems, endogenous stem and progenitor cells fuel the …