Oxytocin and vasopressin agonists and antagonists as research tools and potential therapeutics

M Manning, A Misicka, A Olma… - Journal of …, 2012 - Wiley Online Library
We recently reviewed the status of peptide and nonpeptide agonists and antagonists for the
V1a, V1b and V2 receptors for arginine vasopressin (AVP) and the oxytocin receptor for …

Diagnosis and management of central diabetes insipidus in adults

A Garrahy, C Moran, CJ Thompson - Clinical endocrinology, 2019 - Wiley Online Library
Central diabetes insipidus (CDI) is characterized by hypotonic polyuria due to impairment of
AVP secretion from the posterior pituitary. In clinical practice, it needs to be distinguished …

Peptide and non-peptide agonists and antagonists for the vasopressin and oxytocin V1a, V1b, V2 and OT receptors: research tools and potential therapeutic agents

M Manning, S Stoev, B Chini, T Durroux… - Progress in brain …, 2008 - Elsevier
Oxytocin (OT) and vasopressin (AVP) mediate their biological actions by acting on four
known receptors: The OT (uterine) and the AVP V 1a (vasopressor), V 1b (pituitary), V 2 …

Vasopressin and its analogues: from natural hormones to multitasking peptides

M Glavaš, A Gitlin-Domagalska, D Dębowski… - International journal of …, 2022 - mdpi.com
Human neurohormone vasopressin (AVP) is synthesized in overlapping regions in the
hypothalamus. It is mainly known for its vasoconstricting abilities, and it is responsible for the …

Drugs five years later: desmopressin

DW RICHARDSON, AG ROBINSON - Annals of internal medicine, 1985 - acpjournals.org
Desmopressin (dDAVP), a synthetic analog of the neurohypophyseal nonapeptide arginine
vasopressin, has enhanced antidiuretic potency, markedly diminished pressor activity, and a …

Diagnosis of endocrine disease: the role of the desmopressin test in the diagnosis and follow-up of Cushing's syndrome

DA Vassiliadi, S Tsagarakis - European journal of endocrinology, 2018 - academic.oup.com
Desmopressin is a vasopressin analogue selective for type 2 vasopressin receptors that
mediate renal water retention. In contrast to the native hormone arginine vasopressin, a well …

The desmopressin stimulation test in the differential diagnosis of Cushing's syndrome

DA Malerbi, BB Mendonça, B Liberman… - Clinical …, 1993 - Wiley Online Library
Summary objective We assessed the ability of desmopressin to stimulate the pituitary‐
adrenal axis in patients with Cushing's syndrome. DESIGN AND SUBJECTS The Cortisol …

Management of central diabetes insipidus

A Garrahy, CJ Thompson - … Practice & Research Clinical Endocrinology & …, 2020 - Elsevier
The treatment of central diabetes insipidus has not changed significantly in recent decades,
and dDAVP and replacement of free water deficit remain the cornerstones of treatment. Oral …

A combined test using desmopressin and corticotropin-releasing hormone in the differential diagnosis of Cushing's syndrome

J Newell-Price, L Perry, S Medbak… - The Journal of …, 1997 - academic.oup.com
To assess the ability of desmopressin to differentiate between pituitary and ectopic ACTH-
dependent Cushing's syndrome and to determine whether diagnostic accuracy could be …

[1-(. beta.-mercapto-. beta.,. beta.-cyclopentamethylenepropionic acid), 2-(O-methyl) tyrosine] arginine-vasopressin and [1-(. beta.-mercapto-. beta.,. beta …

M Kruszynski, B Lammek, M Manning… - Journal of medicinal …, 1980 - ACS Publications
As part of our studies on the design and synthesis of antagonists of the vasopressor
response to arginine-vasopressin (AVP), we have synthesized [l-(d-mercapto-/3, J …