[HTML][HTML] Doxorubicin and other anthracyclines in cancers: Activity, chemoresistance and its overcoming
R Mattioli, A Ilari, B Colotti, L Mosca, F Fazi… - Molecular Aspects of …, 2023 - Elsevier
Anthracyclines have been important and effective treatments against a number of cancers
since their discovery. However, their use in therapy has been complicated by severe side …
since their discovery. However, their use in therapy has been complicated by severe side …
Employing siRNA tool and its delivery platforms in suppressing cisplatin resistance: approaching to a new era of cancer chemotherapy
Although chemotherapy is a first option in treatment of cancer patients, drug resistance has
led to its failure, requiring strategies to overcome it. Cancer cells are capable of switching …
led to its failure, requiring strategies to overcome it. Cancer cells are capable of switching …
CRISPR/Cas9 technology as a potent molecular tool for gene therapy
Clustered regularly interspaced short palindromic repeats/CRISPR‐associated nuclease 9
(CRISPR‐Cas9) is an RNA‐guided gene editing tool which offers several advantageous …
(CRISPR‐Cas9) is an RNA‐guided gene editing tool which offers several advantageous …
53BP1: A key player of DNA damage response with critical functions in cancer
M Mirza-Aghazadeh-Attari, A Mohammadzadeh… - DNA repair, 2019 - Elsevier
Maintenance of genome integrity and stability is a critical responsibility of the DNA damage
response (DDR) within cells, such that any disruption in this kinase-based signaling …
response (DDR) within cells, such that any disruption in this kinase-based signaling …
Targeting PI3K/Akt/mTOR signaling pathway by polyphenols: Implication for cancer therapy
Cancer is one of the biggest challenges facing medicine and its cure is regarded to be the
Holy Grail of medicine. Therapy in cancer is consisted as various artificial cytotoxic agents …
Holy Grail of medicine. Therapy in cancer is consisted as various artificial cytotoxic agents …
[HTML][HTML] The interaction between miRNAs/lncRNAs and Notch pathway in human disorders
S Ghafouri-Fard, MC Glassy, A Abak… - Biomedicine & …, 2021 - Elsevier
Notch pathway is a signaling cascade with important impacts on cell proliferation,
differentiation, developmental processes and tissue homeostasis. This pathway also …
differentiation, developmental processes and tissue homeostasis. This pathway also …
Overcoming doxorubicin resistance in cancer: siRNA-loaded nanoarchitectures for cancer gene therapy
Gene therapy can be used as a cancer therapy by affecting signaling networks participating
in the aggressive behavior of tumors. Small interfering RNA (siRNA) is a genetic tool …
in the aggressive behavior of tumors. Small interfering RNA (siRNA) is a genetic tool …
Crosstalk between Phosphoinositide 3‐kinase/Akt signaling pathway with DNA damage response and oxidative stress in cancer
Abstract The phosphatidylinositol 3‐kinases (PI3K)/Akt signaling pathway is one of the well‐
characterized and most important signaling pathways activated in response to DNA …
characterized and most important signaling pathways activated in response to DNA …
Molecular avenues in targeted doxorubicin cancer therapy
S Roychoudhury, A Kumar, D Bhatkar… - Future Oncology, 2020 - Taylor & Francis
In recent, intra-and inter-tumor heterogeneity is seen as one of key factors behind success
and failure of chemotherapy. Incessant use of doxorubicin (DOX) drug is associated with …
and failure of chemotherapy. Incessant use of doxorubicin (DOX) drug is associated with …
Mucoadhesive curcumin crosslinked carboxy methyl cellulose might increase inhibitory efficiency for liver cancer treatment
Curcumin is a more efficient polyphenol than many chemotherapeutics. It can inhibit many
signaling pathways at the same time resulting in modulation and down regulation for many …
signaling pathways at the same time resulting in modulation and down regulation for many …