Regulator of telomere elongation 1 (RTEL1) is known as a DNA helicase that is important for
telomeres and genome integrity. However, the diverse phenotypes of RTEL1 dysfunction …

Genomes are self-organized and self-maintained as long, complex macromolecules of
chromatin. The inherent heterogeneity, stochasticity, phase separation, and chromatin …

Biomacromolecular folding kinetics involves fast folding events and broad timescales.
Current techniques face limitations in either the required time resolution or the observation …

BG4 is a single-chain variable fragment antibody shown to bind various G-quadruplex (GQ)
topologies with high affinity and specificity, and to detect GQ in cells, including GQ structures …

In this issue of Cell Reports Methods, Molina and colleagues use in vitro single-molecule
DNA flow-stretching to demonstrate the severe effects of appending a short lysine-cysteine …

The guanine-rich telomeric repeats can form G-quadruplexes (G4s) that alter the
accessibility of the single-stranded telomeric overhang. In this study, we investigated the …

DNA and RNA can form various non-canonical secondary structures, including G-
quadruplex (G4) and R-loops. These structures are considered transcriptional regulatory …

Telomeres are nucleoprotein structures at the end of linear chromosomes that eukaryotes
evolved to solve the end-replication and end-protection problems. Telomeres contain a long …