Melanoma is the most lethal skin cancer that originates from the malignant transformation of
melanocytes. Although melanoma has long been regarded as a cancerous malignancy with …

Methylation of cytosine bases in DNA provides a layer of epigenetic control in many
eukaryotes that has important implications for normal biology and disease. Therefore …

We characterized the mutational landscape of melanoma, the form of skin cancer with the
highest mortality rate, by sequencing the exomes of 147 melanomas. Sun-exposed …

DNA methylation is the most widely studied epigenetic mark and is known to be essential to
normal development and frequently disrupted in disease. The Illumina …

The development and progression of melanoma have been attributed to independent or
combined genetic and epigenetic events. There has been remarkable progress in …

Aberrant DNA methylation is an epigenetic hallmark of melanoma, known to play important
roles in melanoma formation and progression. Recent advances in genome-wide …

There are several definitions of biomarkers. A biomarker is a characteristic that can be
objectively measured and evaluated as an indicator of a physiological as well as a …

Whole-genome sequencing data allow detection of copy number variation (CNV) at high
resolution. However, estimation based on read coverage along the genome suffers from …

The epigenetic impact of DNA methylation in chronic myelogenous leukemia (CML) is not
completely understood. To elucidate its role we analyzed 120 patients with CML for …

Psoriasis is a chronic inflammatory immune-mediated disorder affecting the skin and other
organs including joints. Over 1,300 transcripts are altered in psoriatic involved skin …