During the past few decades, supercritical fluid (SCF) has emerged as an effective
alternative for many traditional pharmaceutical manufacturing processes. Operating active …

High solubility in water and physiological fluids is an indispensable requirement for the
pharmacological efficacy of an active pharmaceutical ingredient. Indeed, it is well …

Many formulation strategies have been employed to improve ocular bioavailability of topical
eye drops. The aim of this study was to develop and evaluate a series of solid lipid …

The novel particle generation processes of Active Pharmaceutical Ingredient (API)/drug
have been extensively explored in recent decades due to their wide-range applications in …

Niclosamide, previously used as an anthelmintic drug is currently being repurposed for its
anticancer activity. Niclosamide is a brick like biopharmaceutical classification system (BCS) …

The study was designed to investigate the feasibility of supercritical carbon dioxide (scCO2)
processing for the preparation of simvastatin (SIM) solid dispersions (SDs) in …

The aim of this study was to prepare and characterise inclusion complexes of a low water-
soluble drug, mefenamic acid (MA), with β-cyclodextrin (β-CD). First, the phase solubility …

Cyclodextrins are widely used in pharmaceutics to enhance the bioavailability of many
drugs. Conventional drug/cyclodextrin complexation techniques suffer from many …

Herein we report the formation of dry powder complexes of ibuprofen (IBU) and
hydroxypropyl-γ-cyclodextrin (HP-γ-CyD) by supercritical CO 2-assisted spray-drying …

The inclusion complexes formed by chalcone and 2′, 4′-dihydroxychalcone with β-
cyclodextrin have been studied combining experimental (phase solubility diagrams, Fourier …