The article discusses advances in osmoregulation and excretion with emphasis on how
multicellular animals in different osmotic environments regulate their milieu intérieur …

The with no lysine (K)(WNK) kinases are an evolutionarily ancient group of kinases with
atypical placement of the catalytic lysine and diverse physiological roles. Recent studies …

This study describes the expression patterns of P-type Na+/K+-ATPase and V-type H+-
ATPase in the larval and adult forms of the mosquito Aedes aegypti and provides insight into …

Classical physiological study of the Malpighian tubule has led to a detailed understanding of
fluid transport and its control across several species. With the sequencing of the Drosophila …

The evolution of specialized excretory cells is a cornerstone of the metazoan radiation, and
the basic tasks performed by Drosophila and human renal systems are similar. The …

With no lysine (K)(WNK) kinases regulate epithelial ion transport in the kidney to maintain
homeostasis of electrolyte concentrations and blood pressure. Chloride ion directly binds …

Background Cold tolerance is a key determinant of temperate insect distribution and
performance. Chill-susceptible insects lose ion and water homeostasis during cold …

Background With No Lysine kinase (WNK) signaling regulates mammalian renal epithelial
ion transport to maintain electrolyte and BP homeostasis. Our previous studies showed a …

Aquatic animals residing in saline habitats either allow extracellular sodium concentration to
conform to environmental values or regulate sodium to lower levels. The latter strategy …

Epithelial ion transport is essential to renal homeostatic function, and it is dysregulated in
several diseases, such as hypertension. An understanding of the insect renal (Malpighian) …