Malignant mesothelioma
BWS Robinson, AW Musk, RA Lake - The Lancet, 2005 - thelancet.com
Malignant mesothelioma is an aggressive, treatment-resistant tumour, which is increasing in
frequency throughout the world. Although the main risk factor is asbestos exposure, a virus …
frequency throughout the world. Although the main risk factor is asbestos exposure, a virus …
Gene expression profiling reveals reproducible human lung adenocarcinoma subtypes in multiple independent patient cohorts
Purpose Published reports suggest that DNA microarrays identify clinically meaningful
subtypes of lung adenocarcinomas not recognizable by other routine tests. This report is an …
subtypes of lung adenocarcinomas not recognizable by other routine tests. This report is an …
Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations
R Bueno, EW Stawiski, LD Goldstein, S Durinck… - Nature …, 2016 - nature.com
Abstract We analyzed transcriptomes (n= 211), whole exomes (n= 99) and targeted exomes
(n= 103) from 216 malignant pleural mesothelioma (MPM) tumors. Using RNA-seq data, we …
(n= 103) from 216 malignant pleural mesothelioma (MPM) tumors. Using RNA-seq data, we …
Development of a prognostic genetic signature to predict the metastatic risk associated with cutaneous melanoma
P Gerami, RW Cook, J Wilkinson, MC Russell… - Clinical Cancer …, 2015 - AACR
Purpose: The development of a genetic signature for the identification of high-risk cutaneous
melanoma tumors would provide a valuable prognostic tool with value for stage I and II …
melanoma tumors would provide a valuable prognostic tool with value for stage I and II …
[HTML][HTML] Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancer
GV Glinsky, O Berezovska… - The Journal of clinical …, 2005 - Am Soc Clin Investig
Activation in transformed cells of normal stem cells' self-renewal pathways might contribute
to the survival life cycle of cancer stem cells and promote tumor progression. The BMI-1 …
to the survival life cycle of cancer stem cells and promote tumor progression. The BMI-1 …
Global Gene Expression Profiling of Pleural Mesotheliomas: Overexpression of Aurora Kinases and P16/CDKN2A Deletion as Prognostic Factors and Critical …
F López-Ríos, S Chuai, R Flores, S Shimizu, T Ohno… - Cancer research, 2006 - AACR
Most gene expression profiling studies of mesothelioma have been based on relatively
small sample numbers, limiting their statistical power. We did Affymetrix U133A microarray …
small sample numbers, limiting their statistical power. We did Affymetrix U133A microarray …
Prediction of docetaxel response in human breast cancer by gene expression profiling
K Iwao-Koizumi, R Matoba, N Ueno, SJ Kim… - Journal of clinical …, 2005 - ascopubs.org
Purpose Docetaxel is one of the most effective anticancer drugs available in the treatment of
breast cancer. Nearly half of the treated patients, however, do not respond to chemotherapy …
breast cancer. Nearly half of the treated patients, however, do not respond to chemotherapy …
Comparison of fibulin-3 and mesothelin as markers in malignant mesothelioma
J Creaney, IM Dick, TM Meniawy, SL Leong, JS Leon… - Thorax, 2014 - thorax.bmj.com
Background Pleural malignant mesothelioma (MM) is a deadly tumour predominantly
associated with asbestos exposure. A reliable diagnostic and prognostic marker for MM will …
associated with asbestos exposure. A reliable diagnostic and prognostic marker for MM will …
GEMS: a system for automated cancer diagnosis and biomarker discovery from microarray gene expression data
A Statnikov, I Tsamardinos, Y Dosbayev… - International journal of …, 2005 - Elsevier
The success of treatment of patients with cancer depends on establishing an accurate
diagnosis. To this end, we have built a system called GEMS (gene expression model …
diagnosis. To this end, we have built a system called GEMS (gene expression model …
Molecular classification of malignant pleural mesothelioma: identification of a poor prognosis subgroup linked to the epithelial-to-mesenchymal transition
A De Reynies, MC Jaurand, A Renier, G Couchy… - Clinical Cancer …, 2014 - AACR
Purpose: Despite research efforts to develop more effective diagnostic and therapeutic
approaches, malignant pleural mesothelioma (MPM) prognosis remains poor. The …
approaches, malignant pleural mesothelioma (MPM) prognosis remains poor. The …