Drosophila olfaction: past, present and future

R Benton - Proceedings of the Royal Society B, 2022 - royalsocietypublishing.org
Among the many wonders of nature, the sense of smell of the fly Drosophila melanogaster
might seem, at first glance, of esoteric interest. Nevertheless, for over a century, the 'nose'of …

Cytokine storm-calming property of the isoquinoline alkaloids in Coptis chinensis Franch

Y Lan, H Wang, J Wu, X Meng - Frontiers in Pharmacology, 2022 - frontiersin.org
Coronavirus disease (COVID-19) has spread worldwide and its effects have been more
devastating than any other infectious disease. Importantly, patients with severe COVID-19 …

[HTML][HTML] In situ cell-type-specific cell-surface proteomic profiling in mice

SA Shuster, J Li, UR Chon, MC Sinantha-Hu… - Neuron, 2022 - cell.com
Cell-surface proteins (CSPs) mediate intercellular communication throughout the lives of
multicellular organisms. However, there are no generalizable methods for quantitative CSP …

Membrane curvature governs the distribution of Piezo1 in live cells

S Yang, X Miao, S Arnold, B Li, AT Ly, H Wang… - Nature …, 2022 - nature.com
Piezo1 is a bona fide mechanosensitive ion channel ubiquitously expressed in mammalian
cells. The distribution of Piezo1 within a cell is essential for various biological processes …

Molecular and cellular mechanisms of teneurin signaling in synaptic partner matching

C Xu, Z Li, C Lyu, Y Hu, CN McLaughlin, KKL Wong… - Cell, 2024 - cell.com
In developing brains, axons exhibit remarkable precision in selecting synaptic partners
among many non-partner cells. Evolutionarily conserved teneurins are transmembrane …

Understanding the molecular diversity of synapses

M van Oostrum, EM Schuman - Nature Reviews Neuroscience, 2024 - nature.com
Synapses are composed of thousands of proteins, providing the potential for extensive
molecular diversity to shape synapse type-specific functional specializations. In this Review …

Coordinated cadherin functions sculpt respiratory motor circuit connectivity

AN Vagnozzi, MT Moore, M Lin, EM Brozost, KC Ritesh… - Elife, 2022 - elifesciences.org
Breathing, and the motor circuits that control it, is essential for life. At the core of respiratory
circuits are Dbx1-derived interneurons, which generate the rhythm and pattern of breathing …

Synaptic promiscuity in brain development

N Wolterhoff, PR Hiesinger - Current Biology, 2024 - cell.com
Precise synaptic connectivity is a prerequisite for the function of neural circuits, yet individual
neurons, taken out of their developmental context, readily form unspecific synapses. How …

Shear stress activates nociceptors to drive Drosophila mechanical nociception

J Gong, J Chen, P Gu, Y Shang, KT Ruppell, Y Yang… - Neuron, 2022 - cell.com
Mechanical nociception is essential for animal survival. However, the forces involved in
nociceptor activation and the underlying mechanotransduction mechanisms remain elusive …

Development and function of the medial amygdala

N Prakash, AA Irqeba, JG Corbin - Trends in Neurosciences, 2024 - cell.com
Across studied vertebrates, the medial amygdala (MeA) is a central hub for relaying sensory
information with social and/or survival relevance to downstream nuclei such as the bed …