Organisms experience dramatic fluctuations in demands and stresses over the course of the
day. In order to maintain biological processes within physiological boundaries, mechanisms …

Tau phosphorylation is regulated by a balance between tau kinase and phosphatase
activities. Disruption of this equilibrium was suggested to be at the origin of abnormal tau …

Inhibiting glycogen synthase kinase-3 (GSK-3) activity via pharmacological intervention has
become an important strategy for treating neurodegenerative and psychiatric disorders. The …

The circadian clock underlies daily rhythms of diverse physiological processes, and
alterations in clock function have been linked to numerous pathologies. To apply chemical …

Oximes have been studied for decades because of their significant roles as
acetylcholinesterase reactivators. Over the last twenty years, a large number of oximes have …

Alzheimer's disease (AD) is an incapacitating neurodegenerative disease that slowly
destroys brain cells. This disease progressively compromises both memory and cognition …

Bipolar disorder (BD) and major depressive disorder (MDD) are heritable neuropsychiatric
disorders associated with disrupted circadian rhythms. The hypothesis that circadian clock …

The world health organization (WHO) estimated that 18 million people are struck by
Alzheimer′ s disease (AD). The USA, France, Germany, and other countries launched …

Indirubin is the crucial ingredient of Danggui Longhui Wan and Qing-Dai, traditional
Chinese medicine herbal formulas used for the therapy of chronic myelocytic leukemia in …

Circadian molecular oscillation is generated by a transcription/translation-based feedback
loop in which CRY proteins play critical roles as potent inhibitors for E-box-dependent clock …