Animal models of inflammation for screening of anti-inflammatory drugs: implications for the discovery and development of phytopharmaceuticals

KR Patil, UB Mahajan, BS Unger, SN Goyal… - International journal of …, 2019 - mdpi.com
Inflammation is one of the common events in the majority of acute as well as chronic
debilitating diseases and represent a chief cause of morbidity in today's era of modern …

[HTML][HTML] Phytochemicals as modulators of M1-M2 macrophages in inflammation

U Saqib, S Sarkar, K Suk, O Mohammad, MS Baig… - Oncotarget, 2018 - ncbi.nlm.nih.gov
Macrophages are critical mediators of the innate immune response against foreign
pathogens, including bacteria, physical stress, and injury. Therefore, these cells play a key …

Medicinal plants used against various inflammatory biomarkers for the management of rheumatoid arthritis

S Singh, TG Singh, K Mahajan… - Journal of Pharmacy …, 2020 - academic.oup.com
Objectives Rheumatoid arthritis is a chronic autoimmune disease manifested clinically by
polyarthralgia associated with joint dysfunction triggering the antibodies targeting against …

[HTML][HTML] Advances in anti-inflammatory medicinal plants and phytochemicals in the management of arthritis: A comprehensive review

Y Gandhi, R Kumar, J Grewal, H Rawat… - Food chemistry …, 2022 - Elsevier
Rheumatoid arthritis (RA) is considered to be an inflammatory disorder whereas OA is not
an overtly inflammatory disorder as RA but certain inflammatory cytokines and periodic …

Anthraquinone derivatives as an immune booster and their therapeutic option against COVID-19

P Khanal, BM Patil, J Chand, Y Naaz - Natural products and …, 2020 - Springer
Anthraquinone derivatives are identified for their immune-boosting, anti-inflammatory, and
anti-viral efficacy. Hence, the present study aimed to investigate the reported anthraquinone …

A comprehensive overview of juvenile idiopathic arthritis: From pathophysiology to management

N Bansal, C Pasricha, P Kumari, S Jangra, R Kaur… - Autoimmunity …, 2023 - Elsevier
Rheumatoid Arthritis (RA) is a progressive autoimmune disease. It is among the most
widespread chronic illnesses in children, with an annual incidence of 1.6 to 23 new …

Effects of anthraquinones on immune responses and inflammatory diseases

D Xin, H Li, S Zhou, H Zhong, W Pu - Molecules, 2022 - mdpi.com
The anthraquinones (AQs) and derivatives are widely distributed in nature, including plants,
fungi, and insects, with effects of anti-inflammation and anti-oxidation, antibacterial and …

Aloe vera gel homogenate shows anti-inflammatory activity through lysosomal membrane stabilization and downregulation of TNF-α and Cox-2 gene expressions in …

S Paul, D Modak, S Chattaraj, D Nandi… - Future Journal of …, 2021 - Springer
Background Aloe vera leaf gel has proven efficacious roles in the amelioration of several
human diseases and illness-conditions. Specific purified gel-derived bio-constituents as well …

Assessment of the anti-inflammatory effects of three rhubarb anthraquinones in LPS-Stimulated RAW264. 7 macrophages using a pharmacodynamic model and …

Y Hu, Y Luo, L Xiang, J Wu, Y Zhang, Y Zeng… - Journal of …, 2021 - Elsevier
Abstract Ethnopharmacological relevance Rhubarb (Rhei Radix et Rhizoma) is a traditional
Chinese medicine, has been used as a strong astringent in China to treat inflammation …

Anti-inflammatory and anti-arthritic effects of taraxasterol on adjuvant-induced arthritis in rats

S Wang, Y Wang, X Liu, L Guan, L Yu… - Journal of …, 2016 - Elsevier
Ethnopharmacological relevance Taraxasterol was isolated from the traditional Chinese
medicinal herb Taraxacum which has been frequently used as a remedy for inflammatory …