[HTML][HTML] Non-alcoholic fatty liver disease: Immunological mechanisms and current treatments

L Petagine, MG Zariwala, VB Patel - World Journal of …, 2023 - ncbi.nlm.nih.gov
Non-alcoholic fatty liver disease (NAFLD) causes significant global disease burden and is a
leading cause of mortality. NAFLD induces a myriad of aberrant changes in hepatocytes at …

Extracellular vesicles as inflammatory drivers in NAFLD

AN Srinivas, D Suresh, PK Santhekadur… - Frontiers in …, 2021 - frontiersin.org
Non-alcoholic fatty liver disease (NAFLD) is a highly prevalent chronic liver disease in most
parts of the world affecting one-third of the western population and a growing cause for end …

[HTML][HTML] Saturated fatty acid-enriched small extracellular vesicles mediate a crosstalk inducing liver inflammation and hepatocyte insulin resistance

I Garcia-Martinez, R Alen, L Pereira, A Povo-Retana… - JHEP Reports, 2023 - Elsevier
Abstract Background & Aims Lipotoxicity triggers non-alcoholic fatty liver disease (NAFLD)
progression owing to the accumulation of toxic lipids in hepatocytes including saturated fatty …

Selective isolation of liver-derived extracellular vesicles redefines performance of miRNA biomarkers for non-alcoholic fatty liver disease

LA Newman, Z Useckaite, J Johnson, MJ Sorich… - Biomedicines, 2022 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease.
Definitive diagnosis of the progressive form, non-alcoholic steatohepatitis (NASH), requires …

Oxidative stress in non-alcoholic fatty liver disease

C Smirne, E Croce, D Di Benedetto, V Cantaluppi… - Livers, 2022 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is a challenging disease caused by multiple
factors, which may partly explain why it still remains an orphan of adequate therapies. This …

Circulating sphingolipids and glucose homeostasis: an update

S Ali-Berrada, J Guitton, S Tan-Chen… - International Journal of …, 2023 - mdpi.com
Sphingolipids are a family of lipid molecules produced through different pathways in
mammals. Sphingolipids are structural components of membranes, but in response to …

Nonalcoholic fatty liver disease (NAFLD): pathogenesis and noninvasive diagnosis

V Dorairaj, SA Sulaiman, N Abu, NA Abdul Murad - Biomedicines, 2021 - mdpi.com
The global prevalence of nonalcoholic fatty liver disease (NAFLD) or metabolic associated
fatty liver disease (MAFLD), as it is now known, has gradually increased. NAFLD is a …

Upregulation of miR-96-5p by bone marrow mesenchymal stem cells and their exosomes alleviate non-alcoholic steatohepatitis: emphasis on caspase-2 signaling …

MO El-Derany, SG AbdelHamid - Biochemical Pharmacology, 2021 - Elsevier
Non-alcoholic steatohepatitis (NASH) has evolved as the most common and devastating
chronic liver disease. This study aimed to explore the underlined mechanism for the …

Circulating microRNA‑135a‑3p in serum extracellular vesicles as a potential biological marker of non‑alcoholic fatty liver disease

H Jiang, Y Qian, Z Shen, Y Liu… - Molecular …, 2021 - spandidos-publications.com
Non‑alcoholic fatty liver disease (NAFLD) is a widespread threat to human health. However,
the present screening methods for NAFLD are time‑consuming or invasive. The present …

Pathological contribution of extracellular vesicles and their microRNAs to progression of chronic liver disease

C Lee, J Han, Y Jung - Biology, 2022 - mdpi.com
Simple Summary Extracellular vesicles (EVs) are membrane-enclosed vesicles secreted
from most types of cells. EVs encapsulate many diverse bioactive cargoes, such as proteins …