Substance use in adolescence is a known risk factor for the development of neuropsychiatric
and substance use disorders in adulthood. This is in part due to the fact that critical aspects …

The endocannabinoid system (ECS) is an important brain modulatory network. ECS
regulates brain homeostasis throughout development, from progenitor fate decision to neuro …

Cannabis sativa is the most widely used illicit drug in the world. Its main psychoactive
component is delta‐9‐tetrahydrocannabinol (THC), one of over 100 phytocannabinoid …

Rationale Adolescent exposure to∆ 9-tetrahydrocannabinol (THC), the psychotropic
constituent of cannabis, might affect brain development, and in rodent models leads to long …

Alterations in cannabinoid CB1 receptor (CB1R) are implicated in various psychiatric
disorders. CB1R participates in both depolarization induced suppression of inhibition (DSI) …

The endocannabinoid system (ECS) regulates brain development and function, energy
metabolism and stress in a sex-, age-and tissue-dependent manner. The ECS comprises …

Aims Acute and chronic Δ 9-THC exposure paradigms affect the body differently. More must
be known about the impact of chronic Δ 9-THC on cannabinoid-1 (CB1R) and mu-opioid …

The consequences of cannabis use, especially in the context of schizophrenia, have gained
increased importance with the legalization of cannabis in North America and across the …

Cannabis is still the most widely used illicit drug around the world. While its use has always
been prevalent among adolescents, recent evidence suggests that its consumption is also …

Rationale The endocannabinoid system makes critical contributions to reward processing,
motivation, and behavioral control. Repeated exposure to THC or other cannabinoid drugs …