Almost 60 years have passed since the initial discovery by Hubel and Wiesel that changes
in neuronal activity can elicit developmental rewiring of the central nervous system (CNS) …

Astrocytes are a large and diverse population of morphologically complex cells that exist
throughout nervous systems of multiple species. Progress over the last two decades has …

Neuronal networks are capable of undergoing rapid structural and functional changes called
plasticity, which are essential for shaping circuit function during nervous system …

Molecular genetic approaches in small model organisms like Drosophila have helped to
elucidate fundamental principles of neuronal cell biology. Much less is understood about …

The assembly of functional neural circuits requires the combined action of progressive and
regressive events. Regressive events encompass a variety of inhibitory developmental …

Glial cells constitute without any dispute an essential element in providing an efficiently
operating nervous system. Work in many labs over the last decades has demonstrated that …

Precise neural circuit assembly is achieved by initial overproduction of neurons and
synapses, followed by refinement through elimination of exuberant neurons and synapses …

Synapse loss is an early feature shared by many neurodegenerative diseases, and it
represents the major correlate of cognitive impairment. Recent studies reveal that microglia …

The precise wiring of the nervous system is a combined outcome of progressive and
regressive events during development. Axon guidance and synapse formation intertwined …

During postembryonic life, hormones, including ecdysteroids, juvenile hormones, insulin-like
peptides, and activin/TGFβ ligands act to transform the larval nervous system into an adult …