Diabetic kidney disease (DKD) is one of the fastest growing causes of chronic kidney
disease and associated morbidity and mortality. Preclinical research has demonstrated the …

Renal fibrosis (RF) is the common pathological manifestation of virtually all chronic kidney
diseases (CKD) and one of the major causes of end-stage renal disease (ESRD), but the …

Acute kidney injury (AKI) is a clinical syndrome characterized by a rapid and significant
decrease in renal function that can arise from various etiologies, and is associated with high …

Acute kidney injury (AKI) frequently occurs in patients with chronic kidney disease (CKD)
and in turn, may cause or accelerate CKD. Therapeutic options in AKI are limited and mostly …

Epithelial–mesenchymal transition (EMT) is an important biological process contributing to
kidney fibrosis and chronic kidney disease. This process is characterized by decreased …

As life expectancy increases in many countries, the prevalence of age-related diseases also
rises. Among these conditions, chronic kidney disease is predicted to become the second …

Inflammation is a key characteristic of both acute and chronic kidney diseases. Preclinical
data suggest the involvement of the NLRP3/Inflammasome, receptor-interacting protein …

Kidney fibrosis is a serious consequence of chronic kidney disease (CKD), and currently,
there is no effective pharmacological treatment available. Cellular communication network-2 …

Background: Tubular senescence is a major determinant of chronic kidney disease (CKD)
and identification of potential therapeutic targets involved in senescent tubular epithelial …

While NLRP3 contributes to kidney fibrosis, the function of most NOD‐like receptors (NLRs)
in chronic kidney disease (CKD) remains unexplored. To identify further NLR members …