From basics to clinical: a comprehensive review on spinal cord injury

NA Silva, N Sousa, RL Reis, AJ Salgado - Progress in neurobiology, 2014 - Elsevier
Spinal cord injury (SCI) is a devastating neurological disorder that affects thousands of
individuals each year. Over the past decades an enormous progress has been made in our …

Sex differences in neuroimmunity and pain

S Rosen, B Ham, JS Mogil - Journal of neuroscience research, 2017 - Wiley Online Library
Differences in the prevalence of chronic pain in women vs. men are well known, and
decades of laboratory experimentation have demonstrated that women are more sensitive to …

Function of microglia and macrophages in secondary damage after spinal cord injury

X Zhou, X He, Y Ren - Neural regeneration research, 2014 - journals.lww.com
Spinal cord injury (SCI) is a devastating type of neurological trauma with limited therapeutic
opportunities. The pathophysiology of SCI involves primary and secondary mechanisms of …

The role of the immune system in the generation of neuropathic pain

M Calvo, JM Dawes, DLH Bennett - The lancet neurology, 2012 - thelancet.com
Persistent pain is a sequela of several neurological conditions with a primary immune basis,
such as Guillain-Barré syndrome and multiple sclerosis. Additionally, diverse forms of injury …

The classification of microglial activation phenotypes on neurodegeneration and regeneration in Alzheimer's disease brain

MM Varnum, T Ikezu - Archivum immunologiae et therapiae experimentalis, 2012 - Springer
Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive
decline of cognitive function. There is no therapy that can halt or reverse its progression …

Role of the immune system in chronic pain

F Marchand, M Perretti, SB McMahon - Nature Reviews Neuroscience, 2005 - nature.com
During the past two decades, an important focus of pain research has been the study of
chronic pain mechanisms, particularly the processes that lead to the abnormal sensitivity …

Post-traumatic inflammation following spinal cord injury

ON Hausmann - Spinal cord, 2003 - nature.com
Inflammatory reaction following a spinal cord injury (SCI) contributes substantially to
secondary effects, with both beneficial and devastating effects. This review summarizes the …

Glia: a novel drug discovery target for clinical pain

LR Watkins, SF Maier - Nature reviews Drug discovery, 2003 - nature.com
In many clinical pain syndromes, painful sensations are greatly amplified so that normally
innocuous sensations, such as light touch or warmth, are perceived as pain. Presently …

The role of neuroinflammation and neuroimmune activation in persistent pain

JA DeLeo, RP Yezierski - Pain, 2001 - Elsevier
Interest in neuroinflammation and neuroimmune activation has grown rapidly in recent years
with the recognition of the role of central nervous system (CNS) inflammation and immune …

Drug delivery, cell-based therapies, and tissue engineering approaches for spinal cord injury

S Kabu, Y Gao, BK Kwon, V Labhasetwar - Journal of Controlled Release, 2015 - Elsevier
Spinal cord injury (SCI) results in devastating neurological and pathological consequences,
causing major dysfunction to the motor, sensory, and autonomic systems. The primary …