Human immunodeficiency virus type 1 (HIV-1) infection persists despite years of
antiretroviral therapy (ART). To remove the stigma and burden of chronic infection …

Despite anti-retroviral therapy (ART), human immunodeficiency virus-1 (HIV)-related
pulmonary disease continues to be a major cause of morbidity and mortality for people living …

BACKGROUND Understanding HIV dynamics across the human body is important for cure
efforts. This goal has been hampered by technical difficulties and the challenge of obtaining …

The question of whether the human brain is an anatomical site of persistent HIV-1 infection
during suppressive antiretroviral therapy (ART) is critical, but remains unanswered. The …

BACKGROUND Persistence of HIV in sanctuary sites despite antiretroviral therapy (ART)
presents a barrier to HIV remission and may affect neurocognitive function. We assessed …

While the advent of combination antiretroviral therapy (cART) has dramatically increased the
life expectancy of HIV-1 infected individuals, paradoxically, however, the prevalence of HIV …

Although antiretroviral therapies (ARTs) potently inhibit HIV replication, they do not eradicate
the virus. HIV persists in cellular and anatomical reservoirs that show minimal decay during …

HIV persists in tissues during antiretroviral therapy (ART), but the relative contribution of
different anatomical compartments to the viral reservoir in humans remains unknown. We …

Chimeric Antigen Receptor (CAR) T-cells have emerged as a powerful immunotherapy for
various forms of cancer and show promise in treating HIV-1 infection. However, significant …

The elimination of both cellular and tissue latent reservoirs is a challenge toward a
successful HIV cure.“Shock and Kill” are among the therapeutic strategies that have been …